UID:
almafu_9958103965502883
Umfang:
1 online resource (270 p.)
ISBN:
3-318-00272-0
Serie:
Frontiers in diabetes ; vol. 14
Inhalt:
The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidative stress and advanced glycation end products as well as the significance of alterations in lipoprotein structure are considered. Finally, the pericyte loss in retinopathy and microalbuminuria as related to cardiovascular risk are discussed. Taken as a whole, the contributions included in this book represent a large body of information that will be of great interest to diabetologists, endocrinologists and internists interested in both the basic and clinical aspects of diabetes and its complications.
Anmerkung:
"5th International Diabetes Conference, Turin, April 10-12, 1997."
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""Contents""; ""Preface""; ""Chapter I: Insulin Secretion""; ""Insulin Secretion in Type II Diabetes Therapeutic Approach by Novel Nutrients""; ""The Distinction between �Glucose Setpoint�, �Glucose Threshold� and �Glucose Sensor� Is Critical for Understanding the Role of the Pancreatic [beta]-Cell in Glucose Homeostasis""; ""Chapter II: Insulin Action""; ""The 6-Phosphofructo-2-Kinase/Fructose- 2,6-Bisphosphatase System: Regulation by Insulin and an Insulinomimetic Approach to Lowering Blood Glucose Levels""
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""Metabolic Aspects of Glycogen Synthase Activation Its Role in the Pathogenesis of Insulin Resistance and Hypoglycemia""""Regulation of Glucose Oxidation and Pyruvate Dehydrogenase Activity in Human SkeletalMuscle""; ""Chapter III: Mechanisms of Diabetic Complications""; ""Glucose Phosphorylation in Non-Insulin-Sensitive Tissues""; ""Oxidative Stress and Cardiovascular Complications of Diabetes""; ""The Advanced Glycosylation End Products""; ""Lipoprotein Structure in Type II Diabetes""; ""Cellular Effects of Elevated Glucose Concentrations and Diabetic Retinopathy""
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""A Cellular Approach to the Pathogenesis of Diabetic Retinopathy""""Vascular Remodelling in Diabetic Retinopathy""; ""Advanced Glycation End Products and Loss of Pericytes in Early Diabetic Retinopathy""; ""Microalbuminuria and Cardiovascular Risk""; ""Chapter IV: Short Communications""; ""No Evidence of the Mitochondrial DNA(t-RNALeu(UUR)) Mutation in Unselected NIDDM Patients""; ""Evaluation of in vitro Function of Isolated Human Pancreatic Islets during Long-Term (4Weeks) Culture""; ""Genetic Approaches to theMechanisms and Biology ofSignal Transduction by Insulin andIGF-1 Receptors""
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""Use of Recombinant Adenovirus- Mediated Gene Transfer to Study Insulin Action in 3T3L1 Adipocytes""""Regulation of Insulin Signaling in the Skeletal and CardiacMuscles of Diabetic Rats""; ""Effects of Metformin on Intestinal and Pancreatic Endocrine Secretion in Type 2 (Non-Insulin-Dependent) Diabetes""; ""Predictive Value of Fasting Plasma Glucose versus Post-Load Glucose in the Progression to Non-Insulin-Dependent Diabetesmellitus in Obese Subjects""; ""Non-Insulin-Dependent Diabetes mellitus and Liver Cirrhosis Effect of Treatment with Acarbose""
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""High Glucose Effects on Endothelial Cell Replication in vitro""""Is Raised Blood Pressure during Postural Changes, Rather than Basal Hypertension, a Risk for Diabetic Retinopathy?""; ""Kinetic Characteristics of Glucose Phosphorylation in the Rabbit Lens""; ""Impaired Platelet Sensitivity to the Anti-Aggregating Effects of Adenosine in Obesity and Obese Non-Insulin-Dependent Diabetes mellitus""; ""Antioxidant Enzyme Activities in Retinal Microvascular Cells Are Altered by a Diabetic Environment""
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""Kinetic Parameters of Erythrocyte Sodium-Hydrogen Exchange in Type I Insulin-Dependent Diabetesmellitus""
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English
Weitere Ausg.:
ISBN 3-8055-6644-1
Sprache:
Englisch
