UID:
edocfu_9959239853402883
Format:
1 online resource (378 p.)
ISBN:
1-84816-077-1
Content:
This invaluable volume, written by group of internationally established scientists, presents an overview of the most recent findings on the biology of neutrophils. These cells have become a focus of attention in recent years because of their fascinating biochemistry and molecular biology and their ability to affect the functions of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It presents new information that has never be
Note:
Description based upon print version of record.
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PREFACE; LIST OF CONTRIBUTORS; CONTENTS; CHAPTER 1 MOLECULAR BASIS OF NEUTROPHIL ACTIVATION; 1. A Cell of Discovery; 2. Signal Transduction: Communication Across the Plasma Membrane; 2.1 General considerations; 2.2 Advantage: Neutrophil; 2.3 Molecular probes; 2.4 Metabolic agonists; 3. Molecular Pathways of Cellular Activation; 3.1 G protein-coupled receptors; 3.1.1 Neutrophil migration; 3.2 Tyrosine phosphorylation and neutrophil activation; 3.2.1 Tyrosine-kinase dependent chemotactic responses; 3.3 PIP 3 and the role of PI3 kinase; 3.4 Role of PLD in stimulated Neutrophils
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3.4.1 Phosphatidic acid and oxidative activation4. Activation of PLD; 5. Concluding Remarks: Joining Upstream and Downstream Processes; 6. References; CHAPTER 2 THE RESPIRATORY BURST OF NEUTROPHILS: OXIDATIVE PATHWAYS FOR THE INITIATION OF TISSUE DAMAGE AT SITES OF INFLAMMATION; 1. Introduction; 2. Respiratory Burst Oxidase; 3. Oxidative Killing Mechanisms; 3.1 Superoxide; 3.2 Hydrogen peroxide; 3.3 Myeloperoxidase-hydrogen peroxide-chloride system; 3.4 Hydroxyl radical; 3.5 Singlet oxygen; 3.6 Reactive nitrogen species; 4. Phagocytes, Myeloperoxidase and Oxidative Damage of Tissue
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4.1 Tyrosyl radical4.2 Human phagocytes use myeloperoxidase to generate a family of tyrosine oxidation products by a tyrosyl radical-dependent pathway; 4.3 Tyrosyl radical promotes the cross-linking of tyrosine residues in proteins; 4.4 Tyrosyl radical peroxidizes lipid moieties of LDL; 4.5 Myeloperoxidase converts tyrosine to a reactive aldehyde by an HOCl-dependent reaction; 4.6 Myeloperoxidase generates chlorine gas; 4.7 Myeloperoxidase chlorinates cholesterol; 5. Active Myeloperoxidase is Present in Human Atherosclerotic Lesions
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6. Oxidation Products Generated by Myeloperoxidase are Present in Human Atherosclerotic Lesions7. Conclusions; 8. References; CHAPTER 3 MECHANISM OF LEUKOCYTE ACCUMULATION IN POSTISCHEMIC TISSUES: ROLE OF OXYGEN FREE RADICALS; 1. Introduction; 2. Effects of Oxidants and Oxygen Free Radicals on PMN Adhesion Molecule Expression and Functional Adhesion; 3. Effects of Oxidants and Oxygen Free Radicals on CD18 Mediated PMN Adhesion in the Postischemic Heart; 4. Conclusion; 5. References; CHAPTER 4 REGULATION OF NEUTROPHIL FUNCTIONS BY FATTY ACIDS; 1. Introduction
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2. Sources of Arachidonic Acid and Other Fatty Acids2.1 De novo synthesis; 2.2 Diet; 2.3 Phospholipase A; 3. Transport and Uptake of Fatty Acids; 4. Metabolism of Arachidonic Acid and Other Fatty Acids; 4.1 General; 4.2 Metabolism in neutrophils; 4.2.1 5-lipoxygenase; 4.2.2 12-lipoxygenase; 4.2.3 15-lipoxygenase; 4.2.4 Cyclooxygenase; 4.2.5. ω-oxidation; 5. Transcellular Metabolism; 6. Biological Properties of Arachidonic Acid; 6.1 Effects on neutrophil adhesion, cell migration and chemotaxis; 6.2 Activation of the NADPH oxidase; 6.3 Stimulation of degranulation
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7. Effects of n-3 Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid on Neutrophils
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English
Additional Edition:
ISBN 1-86094-082-X
Language:
English
