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  • 1
    Online Resource
    Online Resource
    Weinheim :Wiley-VCH,
    UID:
    edocfu_9959327482402883
    Format: 1 online resource (xvi, 262 pages) : , illustrations
    ISBN: 9783527606351 , 3527606351 , 3527601872 , 9783527601875
    Series Statement: Methods and principles in medicinal chemistry ; v. 20
    Content: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive hi.
    Note: Protein Crystallography in Drug Discovery; Contents; Preface; A Personal Foreword; List of Contributors; 1 Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes; 2 Kinases; 3 The Proteasome as a Drug Target; 4 Antibiotics and the Ribosome; 5 Structure-Based Design of Cathepsin K Inhibitors; 6 Structure-Based Design of Potent and Selective Cdk4 Inhibitors; 7 Crystallization and Analysis of Serine Proteases with Ecotin; 8 X-ray Crystallography in the Development of Orthogonal LigandReceptor Pairs; 9 Engineering Proteins to Promote Crystallization. , 10 High-throughput Crystallography11 Micro-Crystallization; Subject Index.
    Additional Edition: Print version: Protein crystallography in drug discovery. Weinheim : Wiley-VCH, ©2004 ISBN 9783527306787
    Language: English
    Keywords: Electronic books.
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