Kooperativer Bibliotheksverbund

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Format: 1 online resource : , illustrations (some color)

ISBN: 0-12-809694-2 , 0-12-809454-0

Note: Front Cover -- Type 2 Diabetes and Dementia -- Type 2 Diabetes and Dementia -- Copyright -- Contents -- List of Contributors -- Foreword -- 1 - Introduction -- REFERENCES -- 2 - Epidemiology of Type 2 Diabetes and Dementia -- INTRODUCTION -- CONSIDERATIONS WHEN EVALUATING THE OBSERVATIONAL EPIDEMIOLOGIC LITERATURE -- EPIDEMIOLOGIC STUDIES EVALUATING THE ASSOCIATION OF TYPE 2 DIABETES AND LATE-ONSET DEMENTIAS -- Diabetes and Dementia Are Syndromes -- Type 2 Diabetes and Mild Cognitive Impairment or Cognition and Cognitive Decline -- Vascular and Metabolic Risk Factors and Comorbidities -- Genetic Influences on the Type 2 Diabetes-Dementia Association -- Ethnoracial Considerations -- Brain Outcomes and Biological Markers -- Intervention and Prevention Studies -- Insulin Therapies -- Oral Hypoglycemic Agents -- Prevention Studies -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- 3 - Magnitude and Trajectories of Cognitive Dysfunction in Type 2 Diabetes Mellitus -- INTRODUCTION -- TYPE 2 DIABETES AND COGNITIVE DYSFUNCTION -- Type 2 Diabetes and Cognitive Performance (Cross-sectional Evidence) -- Memory -- Attention and Processing Speed -- Executive Function and Working Memory -- Verbal Fluency and Language -- Perceptual-Motor Function -- Global Cognitive Function -- Type 2 Diabetes and Cognitive Decline (Longitudinal Evidence) -- Memory -- Attention and Processing Speed -- Executive Function and Working Memory -- Language and Verbal Fluency -- Perceptual-Motor Function -- Global Cognitive Function -- SUMMARY -- ABBREVIATIONS -- REFERENCES -- 4 - Brain Imaging in Type 2 Diabetes -- INTRODUCTION -- BRAIN MAGNETIC RESONANCE IMAGING STUDIES OF TYPE 2 DIABETES -- Diabetes and Magnetic Resonance Imaging Markers of Cerebrovascular Disease -- Type 2 Diabetes, Cerebral Infarcts, and Cognitive Function. , Type 2 Diabetes, White Matter Hyperintensities, and Cognitive Function -- Type 2 Diabetes, Cerebral Microbleed, and Cognitive Function -- Type 2 Diabetes, Cerebral Perfusion, and Blood-Brain Barrier -- Type 2 Diabetes, Magnetic Resonance Imaging Markers of Neurodegeneration, and Connectivity -- Type 2 Diabetes and Brain Volumes -- Type 2 Diabetes, White Matter Microstructure, and Structural Networks -- Type 2 Diabetes and Functional Connectivity -- POSITRON EMISSION TOMOGRAPHY STUDIES IN TYPE 2 DIABETES -- Fluorodeoxyglucose Positron Emission Tomography Studies in Type 2 Diabetes -- Positron Emission Tomography Studies of Amyloid, Tau, and Neuroinflammation in Type 2 Diabetes -- CONCLUSION -- REFERENCES -- 5 - Cerebrospinal Fluid and Blood-Based Biomarkers in Alzheimer's Disease and Type 2 Diabetes Spectrum Disorders -- INTRODUCTION -- ALZHEIMER'S DISEASE FLUID BIOMARKERS -- ALZHEIMER'S DISEASE BIOMARKERS IN INSULIN RESISTANCE AND TYPE 2 DIABETES -- MARKERS OF INFLAMMATION AND NEURAL INJURY -- MARKERS OF BLOOD-BRAIN BARRIER AND ENDOTHELIAL/VASCULAR FUNCTION -- MARKERS OF RECEPTOR-MEDIATED Β-AMYLOID TRANSPORT -- MARKERS OF MICRORNA EXPRESSION -- MARKERS OF PROTEIN GLYCATION AND OXIDATION -- MARKERS OF EXOSOMAL COMPOSITION -- SUMMARY AND FUTURE DIRECTIONS -- ACKNOWLEDGMENT -- REFERENCES -- 6 - Neuropathological Insights Into the Link Between Type 2 Diabetes and Dementia -- INTRODUCTION -- VASCULAR NEUROPATHOLOGY -- Brain Infarcts -- Atherosclerosis -- Arteriolosclerosis -- Cerebral Amyloid Angiopathy -- Other Pathophysiologies: Blood-Brain Barrier, Lymphatics, and Indirect Vascular Effects -- ALZHEIMER'S DISEASE NEUROPATHOLOGY -- Neuritic Amyloid Plaques -- Neurofibrillary Tangles -- Alzheimer's Disease Neuropathology by Brain Region -- Alzheimer's Disease Neuropathology and Apolipoprotein E ε4. , Other Neurodegenerative Pathologies: Parkinson's Disease, Lewy Body Dementia, and Tauopathies -- SUMMARY AND FUTURE DIRECTIONS -- REFERENCES -- 7 - Diet, Obesity, and Physical Inactivity: Linking Diabetes and Dementia -- INTRODUCTION -- DELETERIOUS EFFECTS OF OBESITY ON NEUROCOGNITION AND THE RELATIONSHIP TO TYPE 2 DIABETES -- Executive and Appetitive Function -- Hippocampal-Dependent Functions -- Dopamine Adaptations -- Hippocampal Dysfunction -- Mood and Emotion -- Effects of Diet and Macronutrients -- Effects of Sedentary Behavior -- BENEFICIAL EFFECTS OF DIET AND PHYSICAL ACTIVITY ON NEUROCOGNITION, AND THE RELATIONSHIP TO NEUROCOGNITIVE DYSFUNCTION IN OBESIT... -- Diet and Macronutrients -- Physical Activity and Exercise -- CONCLUSIONS -- FUTURE DIRECTIONS -- SUMMARY -- REFERENCES -- 8 - The Role of Insulin Resistance and Signaling in Dementia -- INTRODUCTION -- INSULIN AND ITS DIVERSE CELLULAR ACTIONS -- INSULIN AND THE BLOOD-BRAIN BARRIER -- DOES INSULIN SYNTHESIS OCCUR IN THE BRAIN? -- INSULIN'S ACTIONS IN THE BRAIN -- Neurons and Synapses -- Astrocytes -- Oligodendrocytes -- Microglia -- THE OVERARCHING EFFECTS OF INSULIN IN THE BRAIN: METABOLISM AND COGNITION -- Effects on Systemic Metabolism -- Cognitive Function -- BRAIN INSULIN RESISTANCE: AN EMERGING CONSTRUCT -- Type 2 Diabetes-Associated Cognitive Impairment -- Brain Insulin Resistance in Aging, Alzheimer's Disease, and Other Neurodegenerative Disorders -- SUMMARY -- REFERENCES -- 9 - Advanced Glycation, Diabetes, and Dementia -- INTRODUCTION -- ADVANCED GLYCATION END PRODUCTS AND THEIR PRECURSORS -- ADVANCED GLYCATION END PRODUCTS AND THEIR PRECURSORS ACCUMULATE IN TISSUES OF PEOPLE WITH TYPE 2 DIABETES MELLITUS -- NONRECEPTOR MEDIATED INTERACTION OF ADVANCED GLYCATION END PRODUCTS -- Cross-linking of Collagen in Blood Vessels. , ADVANCED GLYCATION END PRODUCT-RECEPTOR FOR ADVANCED GLYCATION END PRODUCT INTERACTION AND GLUCOSE DYSREGULATION IN TYPE 2 DIABE... -- Advanced Glycation End Product-Receptor for Advanced Glycation End Product: Downstream Signaling Pathways Contributing to Reacti... -- Reactive Oxygen Species Formation -- Inflammation and Insulin Resistance -- ADVANCED GLYCATION END PRODUCTS AND THEIR PRECURSORS AS MECHANISTIC FACTORS FOR COGNITIVE DECLINE IN DIABETES: CLINICAL STUDIES -- PHARMACOTHERAPEUTIC INTERVENTION: DECREASING ADVANCED GLYCATION END PRODUCT ACCUMULATION AND SIGNALING TO PREVENT COGNITIVE DECL... -- Receptor for Advanced Glycation End Product Antagonists -- Advanced Glycation End Product Inhibitors/Methylglyoxal Scavengers -- FUTURE PERSPECTIVE -- REFERENCES -- 10 - Neuroinflammation, Type 2 Diabetes, and Dementia -- INTRODUCTION -- TYPE 2 DIABETES AND SYSTEMIC INFLAMMATION -- MICROGLIAL PRIMING, NEUROINFLAMMATION, AND ALZHEIMER'S DISEASE -- TYPE 2 DIABETES AND NEUROINFLAMMATION -- Evidence From Human Studies -- Relevant Animal Models of Type 2 Diabetes -- Genetically Obese (Lepob/ob and Leprdb/db) Mice -- Zucker Diabetic Fatty Rats -- High-Fat Feeding -- Combination Models -- CONCLUSION AND PERSPECTIVES -- REFERENCES -- 11 - The Blood-Brain Barrier in Diabetes Mellitus -- INTRODUCTION -- STRUCTURE AND FUNCTION OF THE BLOOD-BRAIN BARRIER IN HEALTH -- The Blood-Brain Barrier and Cerebrospinal Fluid Circulation -- Transiting From Blood Into the Brain-First Obstacle: The Microvascular Endothelial Cell -- Microvascular Endothelial Cells Selectively Facilitate Blood-Brain Barrier Nutrient Transport -- How Microvascular Endothelial Cell Transport Is Regulated by Other Cells -- Astrocytes Regulate Blood-Brain Barrier (Neurovascular Couplings and Vascular Tone) -- ALTERED BLOOD-BRAIN BARRIER STRUCTURE AND FUNCTION WITH DIABETES. , Structural Brain Microvascular Changes With Diabetes -- Functional Blood-Brain Barrier Changes in Diabetes -- What Is the Effect of Diabetes on Known Transporters Within the Microvascular Endothelial Cell? -- SUMMARY AND CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- 12 - Pharmacological and Nonpharmacological Interventions for Cognitive Impairment and Dementia Related to Type 2 Diabetes and Metabolic Disturbances in Aging -- PHARMACOLOGICAL INTERVENTIONS -- Glycemic Control -- Glucose-Lowering Drugs -- Metformin -- Sulfonylureas -- Thiazolidinediones -- Glucagon-like Peptide-1 -- Dipeptidyl Peptidase IV Inhibitors -- Insulin -- Blood Pressure Control -- NONPHARMACOLOGICAL INTERVENTIONS -- Exercise -- Diet and Nutrition -- Combination Interventions of Diet and Exercise -- Bariatric/Metabolic Surgery -- CONCLUSION AND FUTURE DIRECTIONS -- REFERENCES -- Author Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z -- Subject Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- R -- S -- T -- V -- W -- Z -- Back Cover.

Language: English