Format:
1 Online-Ressource (8 Seiten)
ISSN:
1521-3927
,
1521-3927
Content:
A straightforward access route to multifunctional block copolymers, com- bining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described.Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the α-terminus of thiolactone-based sequence-defined oligomers. Reaction conditions for the stepwise, submonomer synthesis at polar solid supports are optimized, using sequential synthesis on a model resin that enables to isolate and determine the purity of the oligomer segments by liquid chroma- tography–electrospray ionization mass spectrometry analysis. The reaction conditions are used to synthesize PEGylated 5mer precision polymers with defined monomer sequence in good yields and high purity to offer an inter- esting platform of macromolecules with potential for biomedical applications.
Content:
Peer Reviewed
In:
Macromolecular rapid communications, Weinheim : Wiley VCH, 2017, 38,2017,24, 1521-3927
Language:
English
URN:
urn:nbn:de:kobv:11-110-18452/20592-4
URL:
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