Format:
XII, 194, ii
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Diagramme
Content:
Background: Consumption of whole-grain, coffee, and red meat were consistently related to the risk of developing type 2 diabetes in prospective cohort studies, but potentially underlying biological mechanisms are not well understood. Metabolomics profiles were shown to be sensitive to these dietary exposures, and at the same time to be informative with respect to the risk of type 2 diabetes. Moreover, graphical network-models were demonstrated to reflect the biological processes underlying high-dimensional metabolomics profiles. Aim: The aim of this study was to infer hypotheses on the biological mechanisms that link consumption of whole-grain bread, coffee, and red meat, respectively, to the risk of developing type 2 diabetes. More specifically, it was aimed to consider network models of amino acid and lipid profiles as potential mediators of these risk-relations. Study population: Analyses were conducted in the prospective EPIC-Potsdam cohort (n = 27,548), applying a nested case-cohort design (n = 2731, including 692 incident…
Note:
Dissertation Universität Potsdam 2017
Additional Edition:
Erscheint auch als Online-Ausgabe Wittenbecher, Clemens Linking whole-grain bread, coffee, and red meat to the risk of type 2 diabetes Potsdam, 2017
Language:
English
Keywords:
Hochschulschrift
Author information:
Schulze, Matthias Bernd 1970-
