Format:
1 Online-Ressource (xiv, 545 Seiten)
,
Illustrationen, Diagramme
ISBN:
9780128113059
Content:
Front Cover -- The Molecular and Cellular Basis of Neurodegenerative Diseases -- Copyright Page -- Dedication -- Contents -- List of Contributors -- Preface -- 1 Solving the Puzzle of Neurodegeneration -- Introduction: The General Problem of Neurodegeneration -- Epidemiology and Clinical Presentation -- Molecular Pathology -- Genetics -- Molecular Clues to Mechanisms of Pathogenesis -- Common Themes and Controversies in Neurodegeneration -- Animal Models -- Prospects for Therapeutics -- Conclusions and Perspective -- References -- 2 Prion Diseases -- Introduction and Historical Perspective -- Molecular Mechanism of Prion Propagation -- The Cellular Prion Protein: Structure and Proteolytic Processing -- Physiological Function of PrPC -- Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity -- Human Prion Diseases -- Animal Prion Diseases -- Prion Strains and Species Barriers -- Methods for Propagation and Detection of Prions -- Therapeutic Approaches -- PrPC and the Alzheimer's Aβ Peptide -- Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases -- Concluding Remarks -- References -- 3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms -- Quantitative Approach to Basic AD Demographics -- Change Over Time: (i) Biogenesis, Production, and Turnover of Aβ -- Change Over Time: (ii) The Accumulation, Spread, Propagation of Aβ -- Change Over Time: (iii) The Growth and Accumulation of Plaque Cores -- Change Over Time: (iv) Brain Atrophy -- Change Over Time: (v) Cognition -- Clearance Mechanisms and Impaired Phagocytosis -- Calculating Polygenic Risk Scores -- Disease-Modifying Strategies: Models of Aβ Accumulation in Alzheimer's Disease-Implications for Aβ Amyloid-Targeting Therapies -- References.
Additional Edition:
ISBN 9780128113042
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9780128113042
Language:
English
URL:
Volltext
(lizenzpflichtig)
