Umfang:
Online-Ressource (XIV, 582 p. 68 illus, digital)
ISBN:
9783540748052
Serie:
Handbook of Experimental Pharmacology 184
Inhalt:
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.
Inhalt:
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book??'s second part, the presynapti
Anmerkung:
Includes bibliographical references and index
,
Front Matter; Neurotransmitter Release; Pharmacology of Neurotransmitter Release: Measuring Exocytosis; Presynaptic Calcium Channels: Structure, Regulators, and Blockers; Pharmacology of Neurotransmitter Transport into Secretory Vesicles; Core Proteins of the Secretory Machinery; Presynaptic Neurotoxins with Enzymatic Activities; a-Latrotoxin and Its Receptors; Presynaptic Signaling by Heterotrimeric G-Proteins; Presynaptic Metabotropic Receptors for Acetylcholine and Adrenaline/Noradrenaline; Presynaptic Receptors for Dopamine, Histamine, and Serotonin
,
Presynaptic Adenosine and P2Y ReceptorsPresynaptic Metabotropic Glutamate and GABAB Receptors; Presynaptic Neuropeptide Receptors; Presynaptic Modulation by Endocannabinoids; Presynaptic lonotropic Receptors; NO/cGMP-Dependent Modulation of Synaptic Transmission; Therapeutic Use of Release-Modifying Drugs; Back Matter;
Weitere Ausg.:
ISBN 9783540748045
Weitere Ausg.:
Buchausg. u.d.T. Handbook of experimental pharmacology ; 184: Pharmacology of neurotransmitter release Berlin : Springer, 2008 ISBN 9783540748045
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Neurotransmitter
;
Freisetzung
;
Pharmakologie
;
Präsynaptischer Rezeptor
;
Neurotransmitter
;
Freisetzung
;
Pharmakologie
;
Präsynaptischer Rezeptor
;
Aufsatzsammlung
DOI:
10.1007/978-3-540-74805-2
URL:
Volltext
(lizenzpflichtig)
Mehr zum Autor:
Südhof, Thomas C. 1955-
Mehr zum Autor:
Starke, Klaus 1937-2024
