Format:
Online-Ressource (XV, 442 p. 103 illus, digital)
ISBN:
9783540271949
Series Statement:
SpringerLink
Content:
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. TOC:Part I Cell Types and Matrix: Hepatocytes.- Signaling Pathways in Biliary Epithelial Cells.- Stellate Cells.- Kupffer Cells.- Hepatic Sinusoidal Endothelial Cells.- Extracellular Matrix.- Part II Specific Signaling Pathways: IL-6/gp130/Stat3 - Vascular Endothelial Growth Factor Signaling.-. Insulin Pathway.- Nature and Function of Hepatic Tumor Necrosis Factor-a Signaling.- The Fas/FasL Signaling Pathway.- TGF-ß and the Smad Pathway in Liver Fibrogenesis.- Interferon Signaling.- CD14 and Toll Receptor.- The Wnt/ß-Catenin Pathway.- Notch Signaling in Liver Disease.- Extracellular ATP: Emerging Roles of Purinergic Signaling.- Calcium Signaling.- MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival.- PI3K,PTEN and Akt.- TOR Signaling and Cell Growth Control.- Peroxisome Proliferator Activated Receptors.- Transcriptional Response to cAMP in the Liver.- Heme Oxygenase System.- Nitric Oxide.- Hypoxia-Inducible Factor-1 Signaling System.- Cyclins and CDKs in Liver Diseases.- Telomeres amd Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis.- NF-kB.- Ceramide: Cell Regulation from a Lipid Perspective.- Apoptosis and Mitochondria.- Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Diseases.- Biological Clock in the Liver.- Part III Horizons: Pharmacogenomics of Cholestatic Liver Disease.- Proteomics of Signal Transduction Pathways.- Subject Index.
Note:
Includes bibliographical references and index
,
Preliminary; Hepatocytes; Signaling Pathways in Biliary Epithelial Cells; Stellate Cells; Kupffer Cells; Hepatic Sinusoidal Endothelial Cells; Extracellular Matrix; IL-6/gpl30/Stat3; Vascular Endothelial Growth Factor Signaling; Insulin Pathway; Nature and Function of Hepatic Tumor Necrosis Factor-α Signaling; The Fas/FasL Signaling Pathway; Tgf-β and the Smad Pathway in Liver Fibrogenesis; Interferon Signaling; CD14 and Toll Receptor; Extracellular ATP: Important Developments in Purinergic Signaling; MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival
,
PI3K, PTEN and AktTOR Signaling and Cell Growth Control; Peroxisome Proliferator Activated Receptors; Transcriptional Response to cAMP in the Liver; Heme Oxygenase System; Nitric Oxide; Hypoxia-Inducible Factor-1 Signaling System; Cyclins and CDKs in Liver Diseases; Telomeres and Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis; NF-κB; Ceramide: Cell Regulation from a Lipid Perspective; Apoptosis and Mitochondria; Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Disease; The Wnt/β-Catenin Pathway; Biological Clock in the Liver
,
Pharmacogenomics of Cholestatic Liver DiseaseProteomics of Signal Transduction Pathways; Notch Signaling in Liver Disease; Back matter; Calcium Signaling
Additional Edition:
ISBN 9783540229346
Additional Edition:
Buchausg. u.d.T. Signaling pathways in liver diseases Berlin : Springer, 2005 ISBN 3540229345
Additional Edition:
ISBN 9783540229346
Language:
English
Subjects:
Medicine
Keywords:
Leberkrankheit
;
Signaltransduktion
;
Aufsatzsammlung
URL:
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