Format:
Online-Ressource (XI, 393p, digital)
ISBN:
9781597453561
Series Statement:
Cancer Drug Discovery and Development
Content:
The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information.
Note:
Includes bibliographical references and index
,
Haley_FM.pdf; Haley_Ch01.pdf; Haley_Ch02.pdf; Haley_Ch03.pdf; Haley_Ch04.pdf; Haley_Ch05.pdf; Haley_Ch06.pdf; Haley_Ch07.pdf; Haley_Ch08.pdf; Haley_Ch09.pdf; Haley_Ch10.pdf; Haley_Ch11.pdf; Haley_Ch12.pdf; Haley_Ch13.pdf; Haley_Ch14.pdf; Haley_Ch15.pdf; Haley_Ch16.pdf; Haley_Ch17.pdf; Haley_Ch18.pdf; Haley_Ch19.pdf; Haley_Ch20.pdf; Haley_Ch21.pdf; Haley_Ch22.pdf; Haley_Ch23.pdf; Haley_index.pdf; Haley_CP.pdf
Additional Edition:
ISBN 9781588299482
Additional Edition:
Buchausg. u.d.T. EGFR signaling networks in cancer therapy Totowa, N.J. : Humana Press, 2008 ISBN 9781588299482
Additional Edition:
Erscheint auch als Druck-Ausgabe EGFR signaling networks in cancer therapy New York, NY : Humana Press, 2008
Language:
English
Subjects:
Medicine
Keywords:
Epidermaler Wachstumsfaktor-Rezeptor
;
Krebsbekämpfung
;
Epidermaler Wachstumsfaktor-Rezeptor
;
Cytostatikum
DOI:
10.1007/978-1-59745-356-1
URL:
Volltext
(lizenzpflichtig)
