Format:
Online-Ressource (XIII, 163p. 29 illus., 27 illus. in color, digital)
ISBN:
9783642166020
Series Statement:
Research and Perspectives in Alzheimer's Disease
Content:
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Note:
Description based upon print version of record
,
Two Faces of Evil: Cancer and Neurodegeneration; Foreword; Acknowledgments; Contents; Contributors; Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer; The Role of Cdk5 as a Cell Cycle Suppressor in Post-mitotic Neurons; Actin-SRF Signaling in the Developing and Mature Murine Brain; The E3 Ubiquitin Ligase Ube3A Regulates Synaptic Function Through the Ubiquitination of Arc; Targeting Children´s Brain Tumors: Development of Hedgehog Pathway Inhibitors for Medulloblastoma; Primary Cilia as Switches in Brain Development and Cancer
,
Nervous System Aging, Degeneration, and the p53 Familyp53, a Molecular Bridge Between Alzheimer´s Disease Pathology and Cancers?; RNA regulation in Neurodegeneration and Cancer; Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain; Intrinsic Brain Signaling Pathways: Targets of Neuron Degeneration; The miRNA System: Bifurcation Points of Cancer and Neurodegeneration; Molecular Mechanisms for the Initiation and Maintenance of Long-Term Memory Storage; Index;
Additional Edition:
ISBN 9783642166013
Additional Edition:
Buchausg. u.d.T. Two Faces of Evil: Cancer and Neurodegeneration Berlin : Springer, 2011 ISBN 9783642166013
Additional Edition:
ISBN 3642166016
Language:
English
Subjects:
Medicine
Keywords:
Krebs
;
Nervendegeneration
;
Konferenzschrift
DOI:
10.1007/978-3-642-16602-0
URL:
Volltext
(lizenzpflichtig)
Author information:
Christen, Yves 1948-
