Format:
Online-Ressource (digital)
ISBN:
9781461422068
,
9781283445702
Series Statement:
SpringerBriefs in Stem Cells
Content:
Induced Pluripotent Stem (iPS) cells are mature cells that have been genetically reprogrammed so that they return to their embryonic state. It is not yet known if iPS stem cells and embryonic stem cells differ significantly. Today many fundamental belief systems in biology are shifting towards accepting that mature body cells can be reverted to an embryonic state without the help of eggs or embryos. With their changed identities, iPS cells are then ready to serve as new tools for research in the fields of disease pathogenesis, drug discovery, oncology, and cell transplantation. One example of
Note:
Includes bibliographical references and index
,
5.3…Identification of iPSC Colonies5.4…Characterization of Genetic Mutation; 5.5…iPSCs Differentiation into Desired Cell Types; References; 6 Challenges to Therapeutic Potential of hiPSCs; 6.1…Is Reprogramming Necessary for Regenerative Therapies?; References; 7 New Approach to Understand the Biology of Stem Cells; 7.1…Health Versus Disease; 7.2…Changed Paradigm: Reprogramming as Rare But Robust Process; 7.3…From Reductionism to Wholeness; 7.4…More Future Considerations; References; 8 Conclusion; About the Author; Index;
,
Induced Pluripotent Stem Cells; Preface; Contents; 1 Introduction; References; 2 Pluripotent Cells; 2.1…Different Pluripotent Cells; 2.2…Transcriptional Networks and Signaling Pathways of Pluripotency; 2.2.1 Transcriptional Network of Pluripotency; References; 3 Induced Pluripotent Stem Cells (iPSCs); 3.1…Generation the First iPSCs; 3.2…Reprogramming; 3.2.1 Factor Delivery into Target Cells; 3.2.1.1 Integrating Approaches; Retroviruses; Lentiviruses; 3.2.1.2 Excisable Approaches; 3.2.1.3 Non-integrative Approaches; 3.2.1.4 Chemical Reprogramming; 3.2.1.5 MicroRNAs (miRNAs) in Reprogramming
,
References4 Molecular Mechanisms of Pluripotency; 4.1…Steps in Reprogramming; 4.1.1 Increase in the Cell Cycle Rate; 4.1.2 Morphological Changes; 4.1.3 Late Events Toward Pluripotency; 4.2…Mechanisms in Reprogramming; 4.2.1 Genetic Factors; 4.2.2 Signaling Pathways; 4.2.2.1 Wnt Signaling; 4.2.2.2 TGF- beta /Activin/Nodal Signaling; 4.2.2.3 BMP Signaling; 4.2.2.4 p53 Pathway; 4.3…Dynamics of Direct Reprogramming; 4.4…Epigenetic Modifications; 4.5…Similarities and Differences Between iPSCs and ESCs; References; 5 Modeling Disease in a Dish; 5.1…Disease-Specific iPSCs; 5.2…Choosing Cell Sources
Additional Edition:
ISBN 9781461422051
Additional Edition:
Buchausg. u.d.T. Yildirim, Sibel Induced pluripotent stem cells New York : Springer, 2012 ISBN 1461422051
Additional Edition:
ISBN 9781461422051
Language:
English
Subjects:
Biology
Keywords:
Stammzelle
;
Forschung
;
Stammzelle
;
Therapie
DOI:
10.1007/978-1-4614-2206-8
URL:
Volltext
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