Format:
Online-Ressource (XII, 442p. 250 illus., 150 illus. in color, digital)
ISBN:
9783709102152
Series Statement:
SpringerLink
Content:
Rachel Green
Content:
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structu
Note:
Description based upon print version of record
,
Title Page; Copright Page; Preface; Table of Contents; Section I Ribosome structure; 1 Ribosome crystallography: From early evolution to contemporary medical insights; 1. Introduction; 2. Hibernating bears stimulated ribosome crystallization; 3. The ribosome is a polymerase; 4. Structural disorder with functional meaning; 5. On the ribosomal tunnel and initial nascent protein folding; 6. Antibiotics targeting the ribosome: strategies, expectations and problems; 7. The ribosomal core is the optimized vestige of an ancient entity; 8. Conclusion; 9. Future prospects; Acknowledgements; References
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2 Structural studies on decoding, termination and translocation in the bacterial ribosome1. Introduction; 2. Studies on decoding; 2.1. Insights from studies on the 30S subunit; 2.2. Structures of the ribosome with elongation factor Tu and aminoacyl tRNA; 3. Studies on termination; 4. The peptidyl transferase center in the 70S ribosome; 5. Structure of a post-translocation complex of the ribosome with elongation factor G; 6. A structure of a ribosome recycling factor; 7. Conclusions; Acknowledgements; References; 3 Structural studies of complexes of the 70S ribosome; 1. Introduction
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2. Something old, something new: Antibiotics and the ribosome2.1. The macrolides and chloramphenicol revisited; 2.2. The tuberactinomycins; 3. Insights into the regulation of bacterial protein synthesis; 3.1. Regulation at the level of initiation: EF-P and the first peptide bond; 3.2. Nascent chains as regulators of protein synthesis: The TnaC leader peptide; Acknowledgements; References; 4 Interaction of bacterial ribosomes with mRNA and tRNA as studied by X-ray crystallographic analysis; 1. Introduction
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2. How does the ribosome maintain the reading frame of messenger RNA during protein synthesis?2.1. Overview of the mRNA path through the ribosome; 2.2. Network of interactions of the ribosome with the mRNA downstream of the A-site codon; 2.3. Role of tRNA modifications in stabilizing mRNA-tRNA interactions on the ribosome. mRNA kink between P- and E-site codons; 2.4. Interactions of the ribosome with the mRNA region upstream of the P-site codon; 2.5. mRNA movement on the ribosome; 3. Stabilization of tRNA in the A site of the 70S ribosome; References
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5 Genetic and crystallographic approaches to investigating ribosome structure and function1. Introduction; 2. Thermus thermophilus as a model system; 2.1. Genetics of T. thermophilus; 2.2. Ribosomal genes and antibiotic-resistance mutations; 2.3. Streptomycin resistance and dependence; 2.4. Communication between ribosomal protein S12 and EF-Tu; 3. X-ray crystallography of mutant 30S subunits; 3.1. Probing the structural basis for streptomycin dependence; 3.2. Restructuring of the 30S subunit by rRNA modification; 4. Conclusions; References; 6 The packing of ribosomes in crystals and polysomes
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1. Introduction
Additional Edition:
ISBN 9783709102145
Additional Edition:
Buchausg. u.d.T. Ribosomes Wien : Springer, 2011 ISBN 9783709102145
Language:
English
Subjects:
Biology
Keywords:
Ribosom
;
Ribosom
;
Ribosomenproteine
DOI:
10.1007/978-3-7091-0215-2
URL:
Volltext
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