Format:
Online-Ressource (XII, 184 p. 15 illus., 10 illus. in color, online resource)
ISBN:
9781461423676
Series Statement:
Energy Balance and Cancer 4
Content:
Nathan A. Berger
Content:
The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
Note:
Description based upon print version of record
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Energy Balance and Gastrointestinal Cancer; Preface; References; Contents; Contributors; Chapter 1: Obesity and Gastrointestinal Cancers: Epidemiology; 1 Obesity: Definitions; 2 Obesity Rates; 3 Gastrointestinal Cancers: Incidence Rates; 4 Gastrointestinal Cancers: Mortality Rates; 5 Obesity and Metabolic Syndrome; 6 Obesity and Gastrointestinal Cancers: Epidemiological Evidence; 6.1 Obesity and Colorectal Cancers; 6.2 Obesity and Esophageal Cancer; 6.3 Obesity and Gastric Cancer; 6.4 Obesity and Gallbladder Cancer; 6.5 Obesity and Liver Cancer; 6.6 Obesity and Pancreatic Cancer
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7 Obesity and Gastrointestinal Cancer Mortality: Epidemiological Evidence8 Metabolic Syndrome and Gastrointestinal Cancers: Epidemiological Evidence; 9 Conclusions; References; Chapter 2: Genetics of Colon Cancer Susceptibility; 1 Familial Adenomatous Polyposis; 2 Hereditary Nonpolyposis Colon Cancer/Lynch Syndrome; 3 MUTYH-Associated Polyposis; 4 Familial Colorectal Cancer Type X; 5 Hamartomatous Polyposis and Other Rare Syndromes; 6 Genome-Wide Association Studies and Low-Penetrance Mutations; 7 CRC Susceptibility Genes and Energy Balance; References
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Chapter 3: Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation, and Inflammation1 Introduction; 2 Links of Intestinal Tumor Models to Inflammation; 3 The Importance of Nutrients, in Particular Vitamin D and Calcium, in Human Colon Cancer; 4 Insight on Nutrition and Intestinal Cancer from Mouse Models; 5 Cellular and Molecular Effects of Diet and Inflammation on Intestinal Tumorigenesis; 6 Concluding Remarks; References; Chapter 4: The Apc Min/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy; References
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Chapter 5: Obesity and the Pathogenesis of Barrett's Esophagus1 Introduction; 2 Definition: Barrett's Esophagus; 3 GERD and BE; 4 The Cancer Progression Model of Esophageal Adenocarcinoma; 5 Prevalence of BE and EAC; 6 Obesity Is the Key Modifiable Risk Factor at Each Stage of Neoplastic Progression; 6.1 GERD, EAC, and Obesity; 7 BE and Obesity; 7.1 BMI and BE Meta-analysis; 7.2 Central Obesity and BE; 8 Central Obesity and GERD as Comodulators of BE Pathogenesis; 8.1 Evidence for Leptin; 8.2 Evidence for Adiponectin; 8.3 Evidence for Free Fatty Acids
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9 Future Directions: Physical Activity as a Modifiable Risk FactorReferences; Chapter 6: Obesity and Pancreatic Cancer; 1 Pancreatic Cancer; 2 Obesity and Risk of Pancreatic Cancer; 2.1 Body Mass Index; 2.2 Central Adiposity; 2.3 Physical Activity; 3 Obesity and Age of Onset and Survival of Pancreatic Cancer; 3.1 Age of Onset; 3.2 Survival; 3.3 Mortality; 4 Mechanism of Obesity-Related Pancreatic Cancer; 4.1 Adipokines; 4.2 Insulin Resistance; 4.3 Inflammation; 4.4 Genetic Susceptibility; 5 Conclusion; References; Chapter 7: Obesity, Insulin Resistance Pathway Factors, and Colon Cancer
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1 Introduction
Additional Edition:
ISBN 9781461423669
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 978-146-142-366-9
Language:
English
Subjects:
Medicine
DOI:
10.1007/978-1-4614-2367-6
