Umfang:
Online-Ressource (VIII, 478 p. 38 illus., 33 illus. in color, digital)
ISBN:
9783709115114
Serie:
Handbook of Experimental Pharmacology 216
Inhalt:
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.
Anmerkung:
Description based upon print version of record
,
Sphingolipids in Disease; Preface; Contents; Part I: Sphingolipids in Cancer; Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance; 1 Introduction; 2 Sphingolipid Metabolism; 3 Ceramide/S1P Rheostat in Cancer; 4 S1P Signaling; 5 Roles of SK in Cancer Pathogenesis; 5.1 SK1 and Cancer; 5.2 SK2 and Cancer; 6 Role of S1P in Autophagy; 7 SK1/S1P Signaling in Drug Resistance; 8 SK2 and Drug Resistance; 9 S1P/S1PR2 Signaling in Cancer and Drug Resistance; 10 SK/S1P-Mediated Anticancer Therapeutics; 11 Conclusion and Future Perspectives; References
,
Using ASMase Knockout Mice to Model Human Diseases1 Introduction; 1.1 ASMase; 1.2 Ceramide; 1.3 Mechanism of Sphingomyelin/Ceramide Signaling; 1.4 Generation of ASMase Knockout Mice; 2 ASMase Knockout Mice and Human Disease; 2.1 ASMase Knockout Mice for Cancer Radiation Therapy; 2.2 ASMase Knockout Mice for Study of GI Damage; 2.3 ASMase Knockout Mice for Study of Ovarian Damage; 2.4 ASMase Knockout Mice for Study of Brain Diseases; 2.4.1 Niemann-Pick Disease; 2.4.2 Stroke; 2.4.3 Blood-Brain Barrier Dysfunction; 2.5 ASMase Knockout Mice for Study of Lung Diseases
,
2.5.1 Acute Respiratory Distress Syndrome2.5.2 Pulmonary Fibrosis; 2.6 ASMase Knockout Mice for Study of Heart Disease and Diabetes; 2.7 ASMase Knockout Mice for Study of Liver Diseases; 2.8 ASMase Knockout Mice for Study of Infection; 2.9 Perspective; References; New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer; 1 Introduction; 2 Sphingosine Kinase and Cancer; 3 Interaction of Sphingosine 1-Phosphate Receptors and Sphingosine Kinase 1 with Oncogenes; 4 Advances in Sphingosine Kinase Inhibitors; 5 Advances on the Role of S1P Lyase in Cancer
,
6 Advances in Other Specific Cancers6.1 Myeloid Leukaemia; 6.2 Multiple Myeloma; 7 Summary and Future Directions; References; Sphingolipids and Response to Chemotherapy; 1 Introduction; 2 Sphingolipid Metabolism; 3 Sphingolipids and Sensitivity to Chemotherapy; 4 Ceramide Synthases; 5 Sphingomyelinases; 6 Sphingolipid and Chemoresistance; 7 Sphingosine Kinases; 8 Ceramidases; 9 Glucosylceramide Synthase and Gangliosides; 10 Conclusion and Future Directions; References; Lung Cancer and Lung Injury: The Dual Role of Ceramide; 1 Introduction
,
2 The Ceramide-Generating Machinery as the Center of Sphingolipids Biology3 Sphingolipids in Lung Cancer: A Field that Needs Research and Discovery; 4 Cigarette Smoke-Induced Lung Cancer and Lung Injury; 5 Cigarette Smoke-Generated Oxidative Stress and Ceramide Generation in Airway Epithelial Cells; 6 Identifying Neutral Sphingomyelinase 2, a Novel Sphingomyelinase Upregulated in Cigarette Smoke-Induced Lung Injury; 7 Can nSMase2 Activation and Ceramide Generation Support Mitogenic Responses?
,
8 nSMase2-Dependent Ceramide Generation and Exosome Secretion: A Vehicle for Propagation of Oncogenes and miRNA
,
Sphingolipids in Cancer: Sphingosine Kinase / Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance -- Using ASMase knockout Mice to Model Human Diseases -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer -- Sphingolipids and Response to Chemotherapy -- Lung Cancer and Lung Injury: The Dual Role of Ceramide -- Sphingolipids Role in Radiotherapy for Prostate Cancer -- Sphingolipids in Cardio-Reno-vascular diseases: Sphingolipid Metabolism and Atherosclerosis -- Cardiovascular Effects of Sphingosine-1-Phosphate S1P -- Cross-Talk between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease -- Sphingolipids in Inflammation, Infection and Lung Diseases -- Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity -- Sphingolipids in Acute Lung Injury -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases -- Ceramide in Cystic Fibrosis.- Regulation of the Sphingosine Kinase/Sphingosine 1 Phosphate Pathway -- Bacterial Infections and Ceramide -- Viral Infections and Sphingolipids -- Ceramide in Plasma Membrane Repair -- Sphingolipids and Inflammatory Diseases of the Skin -- Sphingolipids in Diabetes -- Sphingolipids in Neuro-psychiatry and Muscle Diseases: Neuronal Forms of Gaucher Disease -- Sphingolipids in Neuroinflammation -- Sphingolipids in Psychiatric Disorders and Pain Syndromes -- Role of Sphingosine-1-Phosphate in Sceletal Muscle Cell Biology.
Weitere Ausg.:
ISBN 9783709115107
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Handbook of experimental pharmacology ; 216: Sphingolipids in disease Wien : Springer, 2013 ISBN 9783709115107
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Sphingolipide
;
Pathogenese
DOI:
10.1007/978-3-7091-1511-4
URL:
Volltext
(lizenzpflichtig)
Mehr zum Autor:
Gulbins, Erich 1966-
