Umfang:
Online-Ressource (1 online resource (182 p.))
,
digital, PDF file(s).
Ausgabe:
Online-Ausg.
ISBN:
9780511605536
,
9780521896283
Inhalt:
A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumours and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.
Anmerkung:
Title from publishers bibliographic system (viewed on 18 Feb 2013)
,
Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Section I: Characterization of cancer stem cells; 1 Purification and characterization of cancer stem cells; 2 Prostate cancer stem cells; 3 Melanoma cancer stem cells; 4 Mammospheres and breast carcinoma; Section II: Therapeutic implications of cancer stem cells; 5 Preventative and therapeutic strategies for cancer stem cells; 6 Targeting acute myelogenous leukemia stem cells; Section III: Targeting cancer stem cell pathways; 7 Hedgehog/GLI signaling in cancer; 8 Targeting the Notch signaling pathway in cancer stem cells
,
9 TGF-beta, Notch, and Wnt in normal andmalignant stem cells: differentiating agents and epigenetic modulationIndex
Weitere Ausg.:
ISBN 9780521896283
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe ISBN 978-052-189-628-3
Sprache:
Englisch
Fachgebiete:
Medizin
DOI:
10.1017/CBO9780511605536
