Umfang:
1 Online-Ressource (684 Seiten)
Ausgabe:
1st ed.
ISBN:
9781788018494
Serie:
Issues in Toxicology no. 39
Inhalt:
The Micronucleus Assay in Toxicology succinctly covers the methods used for the analyses of different cell types in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates, fish and plant based bioassays.
Inhalt:
Cover -- The Micronucleus Assay in Toxicology -- Preface -- Contents -- Section 1 - The Origins of Micronuclei and their Association with Disease -- Chapter 1 - A Short Personal History of Micronuclei -- References -- Chapter 2 - Mechanisms by Which Genotoxins Cause Micronuclei and Other Nuclear Anomalies -- 2.1 Introduction -- 2.2 Molecular Mechanisms by Which Genotoxins Induce MN and Other Nuclear Anomalies -- 2.2.1 The Molecular Mechanisms by Which DNA and Protein Lesions Induced by Genotoxins in Circulating Lymphocytes In Vivo can be E... -- 2.2.2 Important Knowledge Gaps Regarding Mechanisms by Which Genotoxic Chemicals Induce MN in Lymphocytes In Vivo and Ex Vivo -- 2.2.3 Conclusions -- 2.2.4 Further Reading -- References -- Chapter 3 - The Fate of Micronuclei and Micronucleated Cells -- 3.1 Introduction -- 3.2 Possible Fates -- 3.2.1 Degradation or Exclusion of MN -- 3.2.2 Death of MN-containing Cells by Apoptosis -- 3.2.3 Reincorporation of MN into the Main Nucleus -- 3.2.4 Persistence of MN and Micronucleated Cells -- 3.3 Transcriptional Activity of MN -- 3.4 Influence of MN-inducing Agents -- 3.5 Influence of Cell Type on MN Formation -- 3.6 Conclusions -- References -- Chapter 4 - Micronuclei and Their Association with Infertility, Pregnancy Complications, Developmental Defects, Anaemias, Inflammation, Diabetes, Chronic Kidney Disease, Obesity, Cardiovascular Disease, Neurodegenerative Diseases and Cancer -- 4.1 Introduction -- 4.2 Infertility and Pregnancy Complications -- 4.3 Developmental Defects -- 4.4 Anaemias -- 4.5 Inflammation -- 4.6 Obesity, Diabetes and Cardiovascular Disease -- 4.7 Kidney Disease -- 4.8 Neurodegenerative Diseases -- 4.9 Cancer -- 4.9.1 Cancer and MN Prospective Epidemiological Studies -- 4.9.2 MN and Haematological Cancers -- 4.9.3 MN and Oral Cancer, Head and Neck Cancers -- 4.9.4 MN and Colorectal Cancer.
Weitere Ausg.:
ISBN 9781788011341
Sprache:
Englisch
DOI:
10.1039/9781788013604
Mehr zum Autor:
Knasmüller, Siegfried 1956-
