Format:
1 Online-Ressource (VIII, 160 S)
Edition:
Karger eBooks Collection
ISBN:
9783318022452
,
9783318022445
Series Statement:
Endocrine development 23
Content:
In the last few years, rapid progress has taken place in our understanding of the developmental biology of GH secretion and the pivotal role it plays in growth.This book keeps the reader updated on the most important developmental aspects and influences leading to changes in terms of clinical views. In ten chapters, well-known scientists and clinicians cover some of the most important progress made in recent times. The first chapters discuss pituitary gland development and imaging in detail followed by a comprehensive presentation of the genetics of the GH axis. Further chapters present a detailed overview of the epigenetics and bioinformatics of GH.This collection of up-to-date investigative data and reviews is of relevance not only to scientists involved in endocrinology but also to any physician interested in growth and development
Note:
Comprehensive update on developmental aspects of growth
,
""Cover""; ""Front Matter""; ""Contents""; ""Preface""; ""Pituitary Gland Development: An Update""; ""Abstract""; ""Pituitary Gland""; ""Congenital Hypopituitarism and Associated Defects""; ""Overlap between Congenital Hypopituitarism and Midline Defects with Kallmann Syndrome""; ""Conclusions""; ""References""; ""Pituitary Gland Imaging and Outcome""; ""Abstract""; ""Imaging of Normal Pituitary""; ""MRI Phenotypes and Outcome""; ""Conclusions""; ""Key Issues""; ""References""; ""Spectrum of Insulin-Like Growth Factor Deficiency""; ""Abstract""; ""GHSR Defects""
,
""Bioinactive Growth Hormone (Kowarski Syndrome)""""Growth Hormone Receptor Defects""; ""STAT5B Mutations""; ""Activating PTPN11 Mutations""; ""IκBα Mutation""; ""ALS Deficiency""; ""IGF Defects""; ""Digenic and Oligogenic Causality""; ""Diagnostic Approach of Children with IGF-1 Deficiency""; ""Conclusion""; ""References""; ""Downstream Insulin-Like Growth Factor""; ""Abstract""; ""At the Lower End of the GHRH-IGF-1 Axis""; ""IGF-1 Mutations""; ""Molecular Genetics of the IGF-1R""; ""Human IGF-1 Receptor Mutations""; ""Mutations Resulting in Haploinsufficiency of the IGF-1R""
,
""Mutations Affecting IGF-1R Biosynthesis""""Mutations Interfering with Ligand Binding and Transmembrane Signaling""; ""Mutations Disrupting IGF-1R Tyrosine Kinase Activity""; ""Phenotype of Patients with IGF1R Mutations""; ""Treatment of Short Stature in IGF-1R Patients""; ""Conclusions""; ""References""; ""New Detection Methods of Growth Hormone and Growth Factors""; ""Abstract""; ""Evidence for Performance Enhancement and Abuse of Recombinant GH in Sports""; ""How Can the Application of Growth Hormone Be Detected?""; ""The Marker Approach""; ""The Isoform Approach""; ""Conclusion""
,
""References""""Imprinted Anomalies in Fetal and ChildhoodGrowth Disorders: The Model of Russell-Silver and Beckwith-Wiedemann Syndromes""; ""Abstract""; ""Russell-Silver Syndrome""; ""Beckwith-Wiedemann Syndrome""; ""Human Multilocus Imprinting Disorders""; ""Assisted Reproductive Technologies and LOI""; ""Identified Molecular Etiologies of RSS and BWS""; ""Conclusions""; ""Acknowledgments""; ""References""; ""Bioinformatics Tools and Databases for the Study of Human Growth Hormone""; ""Abstract""; ""Basic Analytical Methods""; ""Molecular Genetics of Human Growth Hormone""
,
""Bioinformatics Methods and Databases for Disease Information""""Structural Computational Biology Approaches""; ""Acknowledgements""; ""References""; ""Growth Hormone and Cell Growth""; ""Abstract""; ""Clinical Use of Growth Hormone to Enhance Cell Growth""; ""Growth Hormone and Cell Growth""; ""Growth Hormone Receptor""; ""Unique Importance of STAT5 for Postnatal Growth""; ""Growth Hormone and Stem Cell Recruitment""; ""Growth Hormone Receptor in the Cell Nucleus and Its Role in Cell Proliferation""; ""Proteins Interacting with Extracellular Domain of Nuclear GHR""; ""Conclusions""
,
""References""
Additional Edition:
ISBN 9783318022445
Language:
English
Subjects:
Biology
Keywords:
Somatotropin
;
Insulin-like Growth Factor
;
Entwicklungsbiologie
;
Electronic books
;
Congresses
;
Konferenzschrift
Author information:
Mullis, Primus-E. 1954-2016
