Format:
Online-Ressource
Edition:
Reproduktion Karger eBooks Collection 1997-2009
ISBN:
3805567197
,
9783805567190
,
9783318003253
Series Statement:
Progress in experimental tumor research 35
Content:
Studies of both spontaneous and environmentally induced tumors have demonstrated that there is considerable variation among individuals in their response to carcinogenesis, suggesting that genetic factors influence the likelihood of developing cancer. The increasing availability of genetic markers has enabled researchers to analyze polygenic traits such as cancer predisposition. Animal models have proved to be useful experimental tools for identifying and characterizing such genetic factors. Such a comparative approach helps to identify factors that animals and man have in common and to elucidate the basic mechanism of determining susceptibility.This book brings together some of the most recent advances made in the genetic analysis of cancer susceptibility using animal models. Leading investigators in the field present model systems for studying cancers including liver and stomach cancer, breast cancer, myeloid leukemia, retrovirus-induced lymphoma, pulmonary adenoma and familial adenomatous polyposis. An overview of transgenic and gene knockout mice is given, and in several chapters the implications of these findings for human cancers are discussed. Providing an excellent survey of the field, the book is recommended reading for all scientists and graduate students in experimental cancer research and cancer genomics
Note:
Includes bibliographical references and indexes
,
""Contents""; ""Preface""; ""Multiple Genes Governing Biological Functions in the Genetic Backgrounds of LaboratoryMice and Asian Wild Mice""; ""Overview of Transgenic and Gene Knockout Mice""; ""Alkylation Carcinogenesis in Mice with Altered Levels of DNA Repair Methyltransferase""; ""Cancer Predisposition inMutantMice Defective in the XPC DNA Repair Gene""; ""Myeloid Leukemia: Disease Genes and MouseModels""; ""Genetic and Epigenetic Susceptibility to Endogenous Retrovirus-Induced Lymphomas in SL Mice""; ""Inheritance of Pulmonary Adenoma Susceptibility in Mice""
,
""TSC2 GeneMutant (Eker) Rat Model of a Mendelian Dominantly Inherited Cancer""""Apc Gene KnockoutMice as a Model for Familial Adenomatous Polyposis""; ""A Rat Model System for Predisposition to Stomach Cancer""; ""Genetic and Hormonal Regulation of Murine Hepatocarcinogenesis""; ""Genetics of Skin Tumor Promotion""; ""The Genetic Components of Susceptibility to Breast Cancer in the Rat""; ""Author Index""
Additional Edition:
ISBN 9783318003253
Additional Edition:
ISBN 9783805567190
Language:
English
Subjects:
Medicine
Keywords:
Krebs
;
Prädisposition
;
Tiermodell
