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Inhalt:
Aldehyde oxidases (AOXs) (E.C. 1.2.3.1) are molybdoflavo-enzymes belonging to the xanthine oxidase (XO) family. AOXs in mammals contain one molybdenum cofactor (Moco), one flavin adenine dinucleotide (FAD) and two [2Fe-2S] clusters, the presence of which is essential for the activity of the enzyme. Human aldehyde oxidase (hAOX1) is a cytosolic enzyme mainly expressed in the liver. hAOX1is involved in the metabolism of xenobiotics. It oxidizes aldehydes to their corresponding carboxylic acids and hydroxylates N-heterocyclic compounds. Since these functional groups are widely present in therapeutics, understanding the behaviour of hAOX1 has important implications in medicine. During the catalytic cycle of hAOX1, the substrate is oxidized at Moco and electrons are internally transferred to FAD via the FeS clusters. An electron acceptor juxtaposed to the FAD receives the electrons and re-oxidizes the enzyme for the next catalytic cycle. Molecular oxygen is the endogenous electron acceptor of hAOX1 and in doing so it is reduced and ...
Anmerkung:
Dissertation Universität Potsdam 2022
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Esmaeeli Moghaddam Tabalvandani, Mariam, 1977 - ROS generation in human aldehyde oxidase and the effects of ROS and reactive sulfhydryl on the activity of the enzyme Potsdam, 2021
Sprache:
Englisch
Schlagwort(e):
Aldehydoxidase
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Reaktive Sauerstoffspezies
;
Molybdän
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Cofaktor
;
Enzymaktivität
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Molekularbiologische Methode
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Hochschulschrift
DOI:
10.25932/publishup-53460
URN:
urn:nbn:de:kobv:517-opus4-534600
URL:
https://d-nb.info/1251394868/34
Mehr zum Autor:
Mendel, Ralf-Rainer