Format:
1 Band (verschiedene Seitenzählungen)
,
Illustrationen, Diagramme
Content:
Aging is a complex process characterized by several factors, including loss of genetic and epigenetic information, accumulation of chronic oxidative stress, protein damage and aggregates and it is becoming an emergent drug target. Therefore, it is the utmost importance to study aging and agerelated diseases, to provide treatments to develop a healthy aging process. Skeletal muscle is one of the earliest tissues affected by age-related changes with progressive loss of muscle mass and function from 30 years old, effect known as sarcopenia. Several studies have shown the accumulation of protein aggregates in different animal models, as well as in humans, suggesting impaired proteostasis, a hallmark of aging, especially regarding degradation systems. Thus, different publications have explored the role of the main proteolytic systems in skeletal muscle from rodents and humans, like ubiquitin proteasomal system (UPS) and autophagy lysosomal system (ALS), however with contradictory results. Yet, most of the published studies are performed in ...
Note:
kumulative Dissertation
,
Dissertation Universität Potsdam 2023
Language:
English
Keywords:
Hochschulschrift
Author information:
Rimbach, Gerald 1964-
Author information:
Grune, Tilman 1962-
Author information:
Klaus, Susanne