Format:
1 Online-Ressource (xiv, 194 Seiten, 7502 KB)
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Illustrationen, Diagramme
Content:
Inflammatory bowel diseases (IBD), characterised by a chronic inflammation of the gut wall, develop as consequence of an overreacting immune response to commensal bacteria, caused by a combination of genetic and environmental conditions. Large inter-individual differences in the outcome of currently available therapies complicate the decision for the best option for an individual patient. Predicting the prospects of therapeutic success for an individual patient is currently only possible to a limited extent; for this, a better understanding of possible differences between responders and non-responders is needed. In this thesis, we have developed a mathematical model describing the most important processes of the gut mucosal immune system on the cellular level. The model is based on literature data, which were on the one hand used (qualitatively) to choose which cell types and processes to incorporate and to derive the model structure, and on the other hand (quantitatively) to derive the parameter values. Using ordinary differential ...
Note:
Dissertation Universität Potsdam 2023
Additional Edition:
Erscheint auch als Druck-Ausgabe Stübler, Sabine Mathematical model of the mucosal immune response to study inflammatory bowel diseases and their treatments Potsdam, 2023
Language:
English
Keywords:
Hochschulschrift
DOI:
10.25932/publishup-61230
URN:
urn:nbn:de:kobv:517-opus4-612301
Author information:
Kummer, Ursula 1967-
