Format:
Online-Ressource (XXXVII, 421 S.)
ISBN:
0121822605
,
9780121822606
Series Statement:
Methods in enzymology 357
Content:
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymologyis one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today#151,truly an essential publication for researchers in all fields of life sciences. Key Features * Human Genomics and Genetics * Structure and Mechanism * Regulation of Expression * Metabolism * Invertibrate P450s
Note:
Description based upon print version of record
,
Front Cover; Cytochrome P450; Copyright Page; Table of Contents; Contributors to Volume 357; Preface; Volume in Series; Section I: Human Genomics and Genetics; Chapter 1. Mining Databases for Cytochrome P450 Genes; Chapter 2. Sequence Alignments, Variabilities, and Vagaries; Chapter 3. Human CYP Allele Database: Submission Criteria Procedures and Objectives; Chapter 4. Fine-Scale Mapping of CYP Gene Clusters: An Example from Human CYP4 Family; Chapter 5. Detection of Single Nucleotide Polymorphisms in CYP2B6 Gene; Chapter 6. Genotyping Human Cytochrome: P450 1B1 Variants
,
Chapter 7. Genotyping Human CYP2A6 VariantsSection II: Structure and Mechanism; Chapter 8. Purification and Crystallization of N-Terminally Truncated Forms of Microsomal Cytochrome P450 2C5; Chapter 9. Molecular Replacement in P450 Crystal Structure Determinations; Chapter 10. Optical Biosensor and Scanning Probe Microscopy Studies of Cytochrome P450 Interactions with Redox Partners and Phospholipid Layers; Chapter 11. Cryoradiolysis for the Study of P450 Reaction Intermediates; Chapter 12. Analyzing Binding of N-Terminal Truncated, Microsomal Cytochrome P450s to Membranes
,
Chapter 13. Sensitizer-Linked Substrates and Ligands: Ruthenium Probes of Cytochrome P450 Structure and MechanismChapter 14. Combining Pharmacophore and Protein Modeling to Predict CYP450 Inhibitors and Substrates; Chapter 15. High Pressure: A New Tool to Study P450 Structure and Function; Section III: Regulation of Expression; Chapter 16. Use of in Vitro Pregnane X Receptor Assays to Assess CYP3A4 Induction Potential of Drug Candidates; Chapter 17. Analysis of CYP mRNA Expression by Branched DNA Technology
,
Chapter 18. Ligand-Induced Coactivator Recruitment to Peroxisome Proliferator-Activated Receptora Characterized by Fluorescence Resonance Energy TransferChapter 19. Fluorescence-Based Ligand-Binding Assays for Peroxisome Proliferator-Activated Receptors; Chapter 20. Developing Toxicologically Predictive Gene Sets Using cDNA Microarrays and Bayesian Classification; Chapter 21. Direct Expression of Fluorescent Protein-Tagged Nuclear Receptor CAR in Mouse Liver
,
Chapter 22. Application of Fluorescent Differential Display and Peroxisome Proliferator-Activated Receptor (PPAR)a-Null Mice to Analyze PPAR Target GenesChapter 23. Histological and Metabolism Analysis of P450 Expression in the Brain; Chapter 24. Proteomic Analysis of Rodent Hepatic Responses to Peroxisome Proliferators; Section IV: Metabolism; Chapter 25. Kinetic Analysis for Multiple Substrate Interaction at the Active Site of Cytochrome P450; Chapter 26. Design and Application of Fluorometric Assays for Human Cytochrome P450 Inhibition
,
Chapter 27. Automated Quantitative and Qualitative Analysis of Metabolic Stability:AProcess for Compound Selection during Drug Discovery
,
Literaturangaben
In:
Pt. C
Additional Edition:
Erscheint auch als Druck-Ausgabe Cytochrome P450 ; Pt. C Amsterdam [u.a.] : Acad. Press, 2002 ISBN 0121822605
Language:
English
Keywords:
Electronic books
