Format:
Online-Ressource
,
Ill.
Edition:
Online-Ausg.
ISBN:
0121828085
Series Statement:
Methods in enzymology 403
Content:
Rab GTPases now comprise a family of〉63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. * Comprehensive overview of Rab GTPase phylogeny and systems biology * Identification and characterization of Rab GEFs, GAPs and effectors * General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches
Note:
Includes bibliographical references and index. - Print version record
,
Restricted to licenced organisations with IP address and password
,
Literaturangaben
Additional Edition:
ISBN 9780121828080
Additional Edition:
Erscheint auch als Druck-Ausgabe GTPases regulating membrane targeting and fusion Amsterdam : Elsevier, 2005 ISBN 0121828085
Additional Edition:
ISBN 9780121828080
Language:
English
Subjects:
Biology
Keywords:
Rab-Proteine
;
Membranfusion
;
Regulation
;
Electronic journals
;
Electronic journals
;
Electronic books
;
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