Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences
ISBN:
9781441901347
Content:
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. "Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy" will serve to distill the most salient developme
Note:
Description based upon print version of record
,
Preface; Reference; Contributors; About the Editors; Borsook_Ch01.pdf; The Challenges and Opportunities; Introduction; Failure: A Driving Force for Improved Approaches; New Approaches and Indications; Integration of Processes in CNS Drug Development; Chasing the Ideal: Can Neuroimaging Help?; Animal-Human Translation; CNS Target Engagement and Dosing; Human Surrogate Models; Clinical Phenotype; Pharmaco-Phenotype; Challenges in Adopting Neuroimaging Technologies; References; Borsook_Ch02.pdf; Imaging of CNS Systems: Importance for Drug Development; Introduction
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Imaging Biomarkers for Target-Compound Interaction in Alzheimer's diseaseImaging Biomarkers of Disease and Disease Modification in Alzherimer's Disease; Imaging Biomarkers of Patient Selection in Stroke and Cerebrovascular Disease; Imaging Biomarkers in Schizophrenia; Imaging Biomarkers in Mood Disorders; Conclusions; References; Borsook_Ch03.pdf; Anatomical Imaging: Volumetric Analysis; Introduction; Early Impact of MRI on Clinical Diagnosis: Volumetric Approaches; Refining Definitions of Disease; Implications for CNS Therapy; Analytical Approaches to Assess Whole-Brain Volumetric Change
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Voxel-Based Morphometry and Related Measures of CNS DiseaseThe Role of Whole-Brain Atrophy Measures in CNS Drug Therapy; Distinguishing Measures Contributing to Cortical Density; From Focal Atrophy to Hodology: Imaging Structural Systems in CNS Disease; Methodological Considerations; Analytical Assumptions; Interpreting Measures of Volumetric Changes; Therapeutic Horizons; Conclusion; References; Borsook_Ch04.pdf; Diffusion Tensor Imaging and Drug Development; Introduction; Diffusion Magnetic Resonance Imaging; Physical Concepts; Diffusion Tensor Imaging; Physical Concepts
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Diffusion Tensor Imaging in Human Brain PathologiesOncology; Head Trauma; Huntington's Disease; Pain; Stroke; Multiple Sclerosis; Depression; Autism; Obsessive Compulsive Disorder; Schizophrenia; Alzheimer's Disease; DTI and Drug Development; Oncology; Other Applications; Limitations; Concluding Remarks; References; Borsook_Ch05.pdf; Functional Magnetic Resonance Imaging in Drug Development; Introduction; Measuring the BOLD Response with fMRI; Previous and Common Uses of fMRI; Pharmacological fMRI: Applications in Drug Development
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fMRI of Drug Effects: Interactions Between Drug and Processing of StimulusStandardization and Reproducibility; Nonphysiological; Physiologic or Cognitive; Conclusion; References; Borsook_Ch06.pdf; Magnetic Resonance Imaging of Pharmacological Systems; What Is Pharmacological MRI; What Can Be Measured; Hemodynamic Signals; Animal phMRI-Specific Contrast Mechanisms; Nonhemodynamic-Based Animal phMRI Methods; Resting-State fMRI; Imaging Direct Effect of Drugs; Imaging Indirect Effects of Drugs; Biomarkers; Interpretation of the phMRI Signal; Control Procedures; Analysis Issues; References
,
Borsook_Ch07.pdf
Additional Edition:
ISBN 9781441901330
Language:
English
DOI:
10.1007/978-1-4419-0134-7
URL:
Volltext
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