Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9789048132713
Series Statement:
Advances in Experimental Medicine and Biology 654
Content:
This book is a unique and thoughtful blend of critical background information and advances made in a multitude of areas of contemporary islet research. It is an essential reference book, the first of its kind in many years, for professionals as well as for the beginners interested in the study of islet physiology and diabetes. The book is unique in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of horm
Note:
Includes bibliographical references and index
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Preface; Contents; Contributors; 1 Microscopic Anatomy of the Human Islet of Langerhans; 1.1 Introduction; 1.2 The Islets of Langerhans; 1.3 Embryology and Fetal Development; 1.4 Endocrine Cell Types; 1.4.1α-Cells; 1.4.2 β-Cells; 1.4.3 D-Cells; 1.4.4 PP Cells; 1.4.5 Epsilon Cells; 1.5 Islet Anatomy; 1.6 Non-endocrine Islet Cells; 1.7 Islet Vasculature; 1.8 Innervation; 1.9 Islet in Type 1 Diabetes; 1.10 Islets in Type 2 Diabetes; References; 2 The Comparative Anatomy of Islets; 2.1 Introduction; 2.2 Invertebrates; 2.2.1 Agnatha-CyclostomesFirst Appearance of an Islet Organ
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2.2.2 Chondrichthyes (Jawed Fish)2.2.3 Osteichthyes (Lungfish and Teleost Fish); 2.2.4 Amphibia; 2.2.5 Reptilia (Turtles, Crocodiles, Lizards, Snakes); 2.2.6 Aves; 2.2.7 Mammals; 2.2.7.1 Rodents; 2.2.7.2 Carnivora; 2.2.7.3 Artiodactyls (Even-Toed Ungulates); 2.2.7.4 Marsupials; 2.2.7.5 ArchontaBats, Primates, Tree Shrews; 2.3 Conclusion; References; 3 Approaches for Imaging Islets: Recent Advances and Future Prospects; 3.1 Introduction; 3.2 Optical Imaging Modalities for Islet Imaging; 3.2.1 Laser Scanning Microscopy (LSM); 3.2.2 Optical Projection Tomography
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3.2.3 Bioluminescence Imaging3.3 Nuclear Imaging Modalities for β-Cell Imaging; 3.3.1 Magnetic Resonance Imaging; 3.3.2 Imaging with Radioactive Tracer Molecules; 3.3.2.1 Positron Emission Tomography; 3.3.2.2 Single Photon Emission Computed Tomography; 3.3.2.3 Radiotracer Development; 3.3.2.4 Radiotracer Imaging of -Cells; 3.4 Emerging Technologies for Islet Imaging; 3.5 Concluding Remarks; References; 4 Islet Cell Development; 4.1 Introduction; 4.2 Overview of Pancreas Development; 4.3 Transcriptional Control in Pancreas Development; 4.3.1 Regulators of Pancreatic Progenitors; 4.3.1.1 Pdx1
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4.3.1.2 Ptf1a/p484.3.2 Establishment of the Endocrine Pancreas; 4.3.2.1 Ngn3; 4.3.3 Endocrine Lineages Specification; 4.3.3.1 Pax/Arx; 4.3.3.2 Nkx Transcription Factors; 4.3.4 Maintenance of -Cell Identity; 4.3.4.1 NeuroD/BETA2; 4.3.4.2 MafA; 4.3.4.3 Pdx1; 4.4 Human Islet Cell Development; 4.5 Lessons from Islet Development for Cell Replacement Therapy in Diabetes; References; 5 High Fat Programming of β-Cell Failure; 5.1 Introduction; 5.2 Critical Programming Windows; 5.3 HFP Concept; 5.4 β-Cell Regulation; 5.5 HFP May Induce β-Cell Failure Via Glucolipotoxicity
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5.6 HFP Degrades β-Cell Integrity5.7 HFP: Potential Mechanism of Induction of Type 2 Diabetes; 5.8 Perspectives; References; 6 Nutrient Regulation of Insulin Secretion and β-Cell Functional Integrity; 6.1 Overview of β-Cell Stimulus-Secretion Coupling; 6.2 Phases and Pulsatility of Insulin Secretion; 6.3 Primary Metabolic Factors Regulating Glucose-Stimulated Insulin Secretion; 6.4 Investigating Nutrient Regulation of -Cell Metabolism and Insulin Secretion; 6.5 Mechanisms Underlying β-Cell Actions of Glucose; 6.6 Mechanisms Underlying β-Cell Actions of Lipids
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6.7 Mechanisms Underlying β-Cell Actions of Amino Acids
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Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9789048132706
Additional Edition:
Buchausg. u.d.T. The Islets of Langerhans Dordrecht : Springer, 2010 ISBN 9789048132706
Language:
English
DOI:
10.1007/978-90-481-3271-3
URL:
Volltext
(lizenzpflichtig)
