Format:
Online-Ressource (XII, 168 S.)
Edition:
Online-Ausg. Karger eBooks Collection 1997-2009
ISBN:
9783318014419
,
9783805582469
Series Statement:
Progress in experimental tumor research 39
Content:
This book summarizes the current knowledge on how tumors interact with the nervous system and what impact this might have for the progression and treatment of cancer.It begins with an introduction to the organization and physiology of the nervous system, especially of the peripheral nervous system with its high degree of plasticity. Subsequent chapters discuss the interaction between peripheral nerves and tumor cells, the so-called neuro-neoplastic synapse, with regard to carcinogenesis, predictive tumor markers, tumor growth and tumor progression leading to metastasis. In this part, the concept of neoneurogenesis is postulated as a process by which the tumor regulates its own innervation through the release of neurotrophic factors, in analogy to the process of neoangiogenesis discovered three decades ago. Once nerve endings have grown into the tumor, these can release neurotransmitters which promote tumor cell migration and metastasis development. The final chapters reflect on the role of stem cells in neoneurogenesis and consider pharmacological approaches for the inhibition of neuro-neoplastic interactions as a basis for new anticancer therapies.Targeted primarily at investigators in experimental and clinical oncology, this book is also of special interest to neurobiologists as well as developmental and cell biologists
Note:
Includes bibliographical references and index
,
Cover; Contents; In Remembrance of Fritz Bender Esq. (1907 -1986); Foreword; Neuronal Development; Organization of Peripheral Nerves in Skin, Musculoskeletal System and Viscera; Neurotransmitter Receptor-Mediated Signaling Pathways as Modulators of Carcinogenesis; Neuronal Markers in Non-Neuronal Tissues; Chemotropic Axon Guidance Molecules in Tumorigenesis; Neoneurogenesis and the Neuro-Neoplastic Synapse; Neurotransmitter Effects on Tumor Cells and Leukocytes; Stem Cells and Neurogenesis in Tumors
,
Potential Inhibition of the Neuro-Neoplastic Interactions: The Clue of a GPCR-Targeted TherapyThe Neuro-Neoplastic Synapse: Does it Exist?; Author Index; Subject Index
Additional Edition:
ISBN 9783805582469
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9783805582469
Language:
English
Subjects:
Medicine
DOI:
10.1159/isbn.978-3-318-01441-9
Author information:
Zänker, Kurt S. 1946-
