Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9783034601658
Series Statement:
Milestones in Drug Therapy
Content:
This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.
Note:
Includes bibliographical references and index
,
Title Page; Copyright Page; Table of Contents; List of Contributors; Preface; Gene therapy for arthritis; Gene therapy for the treatment of inflammatory bowel disease; Gene therapy for diabetes; Gene therapy for cystic fibrosis lung disease; Gene therapy of multiple sclerosis; Gene therapy for myositis; Gene therapy for osteoarthritis; Gene therapy: Sjögren's syndrome; Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease; Regulated promoters; Development of AAV vectors for the therapy of autoimmune and inflammatory diseases
,
Delivery and application of plasmid DNA in arthritis gene therapyHelper-dependent adenoviral vectors; Cells as carriers of gene therapy; Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy; Index
,
CoverTable of Contents -- List of Contributors -- Preface -- Gene Therapy for Arthritis -- Why Gene Therapy in Arthritis? -- Ex Vivo Strategy -- In Vivo Strategy -- Vectors for Gene Transfer in Arthritis -- The Target Genes -- Different Promoter to Provide Safe and Targeted Gene Expression -- What Have We Learnt From Preclinical Studies? -- Clinical Experience of Gene Therapy in Ra -- Conclusion -- References -- Gene Therapy for the Treatment of Inflammatory Bowel Disease -- Inflammatory Bowel Disease -- Pathogenesis of Ibd -- Treatment of Ibd 8211; Current Clinical Standards -- Pharmacologic Therapy -- Surgical Therapy -- New Approaches to the Treatment of Ibd -- Blocking Pro-Inflammatory Cytokine Activity -- Anti-Inflammatory Cytokine Treatment -- T Cell Inhibition -- Promoting Intestinal Repair -- Modifying the Enteric Microbiota -- Applications of Nucleic Acid-Based Therapies in Ibd Treatment -- Concluding Remarks -- References -- Gene Therapy for Diabetes -- Introduction -- Approaches for Treating Type 1 Diabetes By Gene Transfer -- Prevention of Autoimmunity By Gene Therapy -- Islet Transplantation With Immunoregulatory Gene Transfection -- Induction of Insulin-Producing Cells From Stem/Progenitor Cells By Gene Transfection -- Reversible Immortalization of Pancreatic 946; Cells By Gene Transfer and Site Specific Recombination -- Conclusions -- References -- Gene Therapy for Cystic Fibrosis Lung Disease -- Introduction -- Cftr Mutations -- Pathophysiology of Cf Lung Disease -- The Low Volume Hypothesis to Explain Cf Lung Disease -- Pharmacological Approaches to Treat Cf Lung Disease -- Drugs That Increase Cftr Protein Levels -- Cftr Correctors, Drugs to Increase Trafficking of Cftr -- Cftr Potentiators, Drugs That Increase Conductance At the Apical Membrane -- Modulation of Other Ion Channels -- Gene Therapy Clinical Trials -- Adenovirus and Adeno-Associated Virus -- Negative Strand Rna Viruses -- Lentiviruses -- Non-Viral Vectors for Cf Gene Therapy -- Cationic Polymers As Mediators for Cf Plasmid Dna Gene Therapy -- Modifier Genes and Future Directions -- Conclusion -- References -- Gene Therapy of Multiple Sclerosis -- Introduction -- Modulation of T Cells By Cytokines -- Interferon-946; -- Interleukin-4 -- Interleukin-10 -- Th17-Treg Cytokines Family -- Decoy Receptors -- Immunotoxins -- Induction of Tolerance -- Innate Immune System -- Angiogenesis -- Antioxidative Therapy -- Stem Cell Mediated Gene Therapy -- Conclusions -- References -- Gene Therapy for Myositis -- Introduction -- Diagnosis -- Immunopathogenesis -- Conventional Therapies -- Gene Therapy -- Gene Therapy in Inflammatory Muscle Disorders -- Targets for Gene Therapy -- Conclusion and Outlook -- References -- Gene Therapy for Osteoarthritis -- Introduction: Osteoarthritis a Disease of Eroding Cartilage -- Current Approaches to Treatment -- Articular Cartilage Matrix Composition and Oa -- Mediator.
,
Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9783034601641
Language:
English
DOI:
10.1007/978-3-0346-0165-8
URL:
Volltext
(lizenzpflichtig)
