UID:
almahu_9947366242302882
Umfang:
1 online resource (2560 p.)
ISBN:
1-281-12522-9
,
0-08-053357-4
Serie:
Cell Biology
Inhalt:
The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation* Events in Intracellular Compartment
Anmerkung:
Description based upon print version of record.
,
Volume 1; Front Cover; Handbook of Cell Signaling; Copyright Page; Table ofContents; Contributors; Preface; Chapter 1. Cell Signaling: Yesterday,Today, and Tomorrow; Origins of Cell Signaling; Enter Polypeptide Growth Factors; Cell Signaling at the Molecular Level; Lipid Signaling; Cell Signaling Tomorrow; References; Part I: Initiation: Extracelluar and Membrane Events; Section A: Molecular Recognition; Chapter 2. Structural and Energetic Basis of Molecular Recognition; Introduction; Principles of Binding; Nonspecific Association with Membrane Surfaces; Protein-Protein Interactions
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ProspectsReferences; Chapter 3. Computational Genomics: Prediction of Protein Functional Linkages and Networks; Introduction; Approaches to Analyzing Protein Functions on a Genome-Wide Scale; Current Issues and Future Prospects for Computing Functional Interactions; References; Chapter 4. Molecular Sociology; Transmembrane Signaling Paradigms; Structural Basis of Protein-Protein Recognition; Conclusion; References; Chapter 5. Free Energy Landscapes in Protein-Protein Interactions; Introduction; Thermodynamics of Protein-Protein Interactions; Interaction Kinetics; The Transition State
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Association of a Protein ComplexDissociation of a Protein Complex; Summary; References; Chapter 6. Antibody-Antigen Recognition and Conformational Changes; Introduction; Antibody Architecture; Conformational Changes; Conclusion; References; Chapter 7. Binding Energetics in Antigen-Antibody Interfaces; Introduction; Thermodynamic Mapping of Antigen-Antibody Interfaces; Conclusions; References; Chapter 8. Immunoglobulin-Fc Receptor Interactions; Introduction; IgG-Receptor Interactions; IgE-Receptor Interactions; Summary; References; Chapter 9. Plasticity of Fc Recognition; Introduction
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Structures of the Natural Fc Binding DomainsThe Consensus Binding Site on Fc; Evolution of an Fc Binding Peptide; Factors Promoting Plasticity; Conserved and Functionally Important Molecular Interactions; Conclusion; References; Chapter 10. Ig-Superfold and Its Variable Uses in Molecular Recognition; Introduction; The Immunoglobulin Superfamily; Ig-Superfold-Mediated Recognition; References; Chapter 11. T-Cell Receptor/pMHC Complexes; TCR Generation and Architecture; Peptide Binding to MHC Class I and II; TCR/pMHC Interaction; Conclusions and Future Perspectives; References
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Chapter 12. Mechanistic Features of Cell-Surface Adhesion ReceptorsMechanosensory Mechanisms; Cell-Cell Adhesions/Adherens Junctions; T-Cell Costimulation; Axon Guidance and Neural Development; Conclusions; References; Chapter 13. The Immunological Synapse; Introduction; Migration and the Immunological Synapse; The Cytoskeleton and the Immunological Synapse; The Role of Self MHCp in T-Cell Sensitivity to Foreign MHCp; Integration of Adaptive and Innate Responses; Summary; References; Chapter 14. NK Receptors; Introduction; Immunoreceptors; Natural Killer Cells; Ig-Type NK Receptors: KIR
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C-Type Lectin-Like NK Receptors: Ly49A
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English
Weitere Ausg.:
ISBN 0-12-124546-2
Sprache:
Englisch
