UID:
almahu_9947367385402882
Umfang:
1 online resource (497 p.)
Ausgabe:
2nd ed.
ISBN:
1-282-71148-2
,
9786612711480
,
0-08-092702-5
Inhalt:
This book provides the ""nuts and bolts"" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.Therefore the book will provide a taste for the subject of glycobiology.Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates
Anmerkung:
Rev. ed. of: Carbohydrates : the sweet molecules of life / Robert V. Stick. 2001.
,
Front Cover; Carbohydrates: The Essential Molecules of Life; Copyright Page; Table of Contents; Preface and Acknowledgements; Abbreviations; CHAPTER 1: The 'Nuts and Bolts' of Carbohydrates; The Early Years; The Constitution of Glucose and Other Sugars; The Cyclic Forms of Sugars, and Mutarotation; The Shape (Conformation) of Cyclic Sugars, and the Anomeric Effect; References; CHAPTER 2: Synthesis and Protecting Groups; Esters; Acetates; Benzoates; Chloroacetates; Pivalates; Levulinates; Carbonates, borates, phosphates, sulfates and nitrates; Sulfonates; Ethers; Methyl ethers; Benzyl ethers
,
4-Methoxybenzyl ethersAllyl ethers; Trityl ethers; Silyl ethers; Acetals; Cyclic acetals; Benzylidene acetals; 4-Methoxybenzylidene acetals; Isopropylidene acetals; Diacetals; Cyclohexylidene acetals; Dithioacetals; Thioacetals; Stannylene acetals; The Protection of Amines; Orthogonality; References; CHAPTER 3: The Reactions of Monosaccharides; Oxidation; Reduction; Halogenation; Non-anomeric halogenation; Anomeric halogenation; Alkenes and Carbocycles; Non-anomeric alkenes; Anomeric alkenes; Carbocycles; Anhydro Sugars; Non-anomeric anhydro sugars; Anomeric anhydro sugars
,
Deoxy, Amino Deoxy and Branched-chain SugarsDeoxy sugars; Amino deoxy sugars; Branched-chain sugars; Miscellaneous Reactions; Wittig reaction; Thiazole-based homologation; Mitsunobu reaction; Orthoesters; Industrially Important Ketoses; D-Fructose; L-Sorbose; Isomaltulose; Lactulose; Aza and Imino Sugars; References; CHAPTER 4: Formation of the Glycosidic Linkage; General; The different glycosidic linkages; The mechanism of glycosidation; Ion pairs and the solvent; The substituent at C2; The 'armed/disarmed' concept; The 'torsional control' concept; The 'latent/active' concept
,
Activation of the glycosyl acceptorThe concept of 'orthogonality'; 'Reciprocal donor/acceptor selectivity'; Hemiacetals; Glycosyl Esters; Glycosyl Halides and Orthoesters; The Koenigs-Knorr reaction (1,2-trans); The orthoester procedure (1,2-trans); Halide catalysis (1,2-cis); Glycosyl fluorides (1,2-cis and 1,2-trans); Glycosyl Imidates (1,2-cis and 1,2-trans); Thioglycosides (1,2-cis and 1,2-trans); Seleno- and Telluroglycosides; Glycosyl Sulfoxides (sulfinyl glycosides; 1,2-cis and 1,2-trans); Glycals; 4-Pentenyl Activation (1,2-cis and 1,2-trans); ß-D-Mannopyranosides (1,2-cis)
,
Glycosyl halidesGlycosyl sulfoxides (and thioglycosides); ß-D-Glucopyranoside to ß-D-mannopyranoside; Intramolecular aglycon delivery; Other methods; ß-Rhamnopyranosides (1,2-cis); 2-Acetamido-2-deoxy Glycosides; 2-Deoxy Glycosides; Sialosides; Furanosides; Miscellaneous Methods; Alkenyl glycosides; Remote activation; C-Glycosides; The addition of carbanions to anomeric electrophiles; The addition of electrophiles to anomeric carbanions; Glycosyl radicals; Miscellaneous; References; CHAPTER 5: Oligosaccharide Synthesis; Strategies in Oligosaccharide Synthesis; Linear syntheses
,
Convergent syntheses
,
English
Weitere Ausg.:
ISBN 0-240-52118-8
Sprache:
Englisch
Fachgebiete:
Chemie/Pharmazie
