UID:
almahu_9947420919902882
Umfang:
1 online resource (1103 p.)
ISBN:
0-12-811354-5
,
1-280-63349-2
,
9786610633494
,
0-08-046006-2
Inhalt:
This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.*Utilizes a multidisc
Anmerkung:
Description based upon print version of record.
,
Front cover; Title page; Copyright page; Table of contents; Contributors; Preface; Color Plates; I. Introduction; 1. Historical Development of Animal Models of Aging; 2. Species Selection in Comparative Studies of Aging and Antiaging Research; 3. Principles of Animal Use for Gerontological Research; 4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes; 5. Models of Systems Failure in Aging; 6. Major Issues in Ethics of Aging Research; 7. Ethical Aspects of Research Involving Elderly Persons; II. General Methods; 8. SAGE KE and Other Online Sources Related to Aging
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9. Proteomics in Aging Research10. Application of High-Throughput Technologies to Aging-Related Research; 11. Models of Alzheimer's Disease; 12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs. Normal Aging; 13. Epidemiology in Aging Research; 14. Statistical Issues for Longevity Studies in Animal Models; 15. Models for the Study of Infection in Populations; 16. Estimation of the Rate of Production of Oxygen Radicals by Mitochondria; III. Animal Models; A. Non-mammalian Systems; 17. Telomeres and Aging in the Yeast Model System; 18. Longevity and Aging in Budding Yeast
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19. From Yeast Methuselah Genes to Evolutionary Medicine20. Strongyloides ratti: A Nematode with Extraordinary Plasticity in Aging; 21. Insect Models for the Study of Aging; 22. Drosophila Models of Aging; 23. Models of Aging in Honeybee Workers; 24. Ants as Naturally Long-lived Insect Models for Aging; 25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster; 26. Annual Fish as a Genetic Model for Aging; 27. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease; 28. Zebrafish as Aging Models; 29. Telomeres in Aging: Birds
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30. Domestic and Wild Bird Models for the Study of AgingB. Mammalian Systems; 31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction; 32. Rat Models of Age-Related Cognitive Decline; 33. Aged Rodents for Biogerontology Research; 34. Life Extension in the Dwarf Mouse; 35. The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology; 36. Bats as a Novel Model for Aging Research; 37. Memory in the Aging Hippocampus: What Can Place Cells Tell Us?; 38. The Rhesus Macaque as a Model of Human Aging and Age-Related Disease
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39. Nonhuman Primates as Models for Reproductive Aging and Human InfertilityIV. Comparative Models; 40. Neurobiology of the Aging Brain; 41. Mitochondrial DNA and Aging; 42. Models for Apoptosis: From Newborn to Adult; 43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence; 44. Model of Chaperones in Aging; 45. Therapeutic Potential of Stem Cells in Aging-Related Diseases; 46. Nuclear Transfer and Cloning: Preservation or Expansion of Proliferative Lifespan?; 47. Human Models of Longevity
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48. Computational Models of Mitochondrial DNA in Aging
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English
Weitere Ausg.:
ISBN 0-12-226860-1
Weitere Ausg.:
ISBN 0-12-369391-8
Sprache:
Englisch
