UID:
almahu_9948026781002882
Umfang:
1 online resource (534 p.)
ISBN:
1-282-28741-9
,
9786612287411
,
0-08-092046-2
Inhalt:
The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism.* Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for
Anmerkung:
Description based upon print version of record.
,
Front Cover; Textbook of Nephro-Endocrinology; Copyright Page; Contents; List of Contributors; Preface; PART I: THE KIDNEY AS AN ENDOCRINE ORGAN; Section I: Erythropoietin; Chapter 1 Erythropoietin: An Historical Overview of Physiology, Molecular Biology and Gene Regulation; I. Introduction; II. Hormonal regulation of erythropoiesis; III. Identification of the site of erythropoietin production; IV. Assays of erythropoietin; V. Isolation and characterization of erythropoietin; VI. Erythropoietin effector mechanisms; VII. Regulation of erythropoiesis by hypoxia
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VIII. Regulatory elements of erythropoietin (EPO) geneIX. Erythropoietin - the paradigm for gene regulation by hypoxia; X. Hypoxia inducible-factor (HIF); XI. The elusive nature of the oxygen sensor; XII. Degradation of HIF by the ubiquitin-proteosomal pathway; XIII. Disruption of the oxygen-sensing pathway in cancer; XIV. Disruption of the oxygen-sensing pathway in hereditary polycythemia; XV. Pharmacological manipulation of HIF; XVI. Summary; References; Chapter 2 Erythropoiesis: The Roles of Erythropoietin and Iron; I. Erythropoiesis: an overview
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II. Role of erythropoietin in erythropoiesisIII. Role of iron in erythropoiesis; References; Chapter 3 Extra-Hematopoietic Action of Erythropoietin; I. Introduction; II. The EPO receptor (EPOR); III. Regulation of EPOR expression; IV. Action of EPO; V. Mechanisms of EPO action; VI. Summary; References; Chapter 4 Development of Recombinant Erythropoietin and Erythropoietin Analogs; I. Introduction; II. History of recombinant human erythropoietin; III. Biosimilar EPOs; IV. Potential strategies for modifying erythropoietin to create new EPO analogs; V. Darbepoetin alfa
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VI. Continuous erythropoietin receptor activator (C.E.R.A.)VII. Small molecule ESAs; VIII. Other strategies for stimulating erythropoiesis; IX. Conclusions; References; Chapter 5 Erythropoietin Anemia and Kidney Disease; I. Introduction; II. Erythropoietin pathophysiology in CKD patients; III. Anemia of chronic kidney disease; IV. Anemia and erythropoietin treatment in children with CKD; V. Conclusions; References; Section II: Vitamin D, PTH and Novel Regulators of Phosphate; Chapter 6 Vitamin D and the Kidney: Introduction and Historical Perspective; I. Introduction; II. Vitamin D
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III. CinacalcetReferences; Chapter 7 Vitamin D: Molecular Biology and Gene Regulation; I. Vitamin D; II. The 1,25-dihydroxyvitamin D/vitamin D receptor complex; III. Relevance of 1,25-dihydroxyvitamin D/VDR actions in health and in kidney disease; IV. Concluding remarks; References; Chapter 8 Molecular Biology of Parathyroid Hormone; I. Introduction; II. Biosynthesis and metabolism; III. PTH receptors; IV. Isoforms; V. Physiological actions of PTH; References; Chapter 9 Endocrine Regulation of Phosphate Homeostasis; I. Introduction; II. Phosphate homeostasis; III. Renal phosphate transport
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IV. Role of phosphate in the regulation of renalvitamin D metabolism
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English
Weitere Ausg.:
ISBN 0-12-373870-9
Sprache:
Englisch
