UID:
almahu_9949460078102882
Ausgabe:
1st ed.
ISBN:
9789175199115
Inhalt:
This thesis by Jonna Idh investigates the role of nitric oxide (NO) in the immune defense against Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). It combines clinical and experimental studies to elucidate NO's function in controlling TB, particularly in patients with pulmonary TB and HIV co-infection. The research finds that low levels of exhaled NO and its metabolites in urine are associated with decreased cure rates in HIV-positive TB patients. Additionally, the study explores the impact of an arginine-rich food supplement (peanuts) on NO production and TB treatment outcomes, suggesting that such supplements may improve cure rates in malnourished, HIV-positive TB patients. The thesis also examines the resistance of M. tuberculosis strains to NO and its correlation with resistance to first-line TB drugs.
Sprache:
Englisch
