UID:
almahu_9949551251102882
Umfang:
1 online resource (248 pages)
Ausgabe:
1st ed.
ISBN:
0-12-820504-0
Inhalt:
Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability. Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets.
Anmerkung:
Front Cover -- NUCLEIC ACIDS -- NUCLEIC ACIDSA NATURAL TARGET FOR NEWLY DESIGNED METAL CHELATE BASED DRUGS -- Copyright -- Contents -- List of contributors -- Abbreviations -- Introduction -- 1 - Zinc complexes: Their interaction with nucleic acids and other biomolecular targets -- 1. Chemistry of zinc -- 2. Interaction of synthesized zinc complexes with nucleic acids -- 3. Methods of analysis -- 3.1 Electronic spectroscopy -- 3.2 Fluorescence spectrometry -- 3.3 Circular dichroism -- 3.4 Electrochemical method -- 3.5 Viscometric studies -- 4. Interaction of zinc complexes with biomolecules -- 4.1 Interaction studies of zinc complexes with DNA -- 4.2 RNA as a drug target -- 4.3 Interaction of zinc complexes with albumin proteins -- 4.4 Interaction studies of zinc complexes with topoisomerase enzymes -- 5. Conclusion -- References -- 2 - Ruthenium complexes: An insight into their interactions with nucleic acids and biomolecules -- 1. Chemistry of ruthenium -- 2. Methods of synthesis -- 2.1 Organometallic Ru(II)-arene complexes -- 2.2 Homoleptic Ru(II) complexes of the type [Ru(L)3]2+ -- 2.3 Heteroleptic Ru(II) complexes of the type [Ru(L1) (L2)2]2+ -- 2.4 Dinuclear Ru(II) complexes -- 3. Methods of analysis -- 3.1 Mass spectroscopy -- 3.2 NMR spectroscopy -- 3.3 X-ray crystallography -- 3.4 Absorption spectroscopic techniques -- 3.5 Fluorescence spectroscopy -- 3.6 Molecular docking -- 4. Uses of metal complexes -- 4.1 Ruthenium complexes as DNA interacting agents -- 4.2 Ruthenium complexes as RNA interacting agents -- 4.3 Ruthenium complexes as other biomolecule interacting agents -- 4.3.1 DNA topoisomerases -- 4.3.2 Serum proteins (HSA/BSA) -- 5. Limitations -- 6. Future prospects -- 7. Conclusions -- References -- 3 - Nucleic acid interactions of copper complexes -- 1. Chemistry of copper -- 2. Methods of synthesis.
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2.1 Cu(I)/(II)-Schiff base complexes -- 2.2 Mononuclear Cu complexes -- 2.3 Dinuclear Cu complexes -- 3. Methods of analysis -- 3.1 EPR spectroscopy -- 3.2 X-ray crystallography -- 3.3 Molecular docking studies -- 3.4 Absorption spectroscopy -- 3.5 Fluorescence spectroscopy -- 4. Uses of metal complexes -- 4.1 DNA-interacting copper complexes -- 4.2 RNA interacting copper complexes -- 4.3 Interaction with other biomolecules -- 5. Limitations -- 6. Future prospects -- 7. Conclusions -- References -- 4 - Recent advances in iron complexes and their interaction with nucleic acids -- 1. Chemistry of iron -- 2. Methods of synthesis -- 2.1 Mononuclear Fe complexes -- 2.2 Dinuclear Fe complexes -- 2.3 Tetranuclear Fe complexes -- 2.4 Heterobimetallic Fe complexes -- 2.5 Schiff base Fe complexes -- 3. Methods of analysis -- 3.1 Absorption spectroscopy -- 3.2 Fluorescence spectroscopy -- 3.3 Circular dichorism spectroscopy -- 3.4 Molecular docking studies -- 4. Uses of metal complexes -- 4.1 DNA interacting iron complexes -- 4.2 RNA-interacting iron complexes -- 4.3 Other biomolecule-interacting iron complexes -- 5. Limitations -- 6. Future prospects -- 7. Conclusions -- References -- 5 - Manganese complexes: Their interaction studies with nucleic acids and biomolecules -- 1. Chemistry of manganese -- 2. Methods of synthesis -- 2.1 Synthesis of neutral di- and trinuclear Mn2+ complexes -- 2.2 Synthesis of manganese corroles -- 2.3 Manganese halide complexes -- 2.4 Synthesis of manganese carbonyl and manganese carbonyl halide complexes -- 2.5 Synthesis of mixed-Mn complexes -- 3. Methods of analysis -- 3.1 Electronic absorption titrations -- 3.2 Fluorescence emission spectroscopy -- 3.3 Electrospray ionization-mass spectrometry and tandem mass spectrometry -- 3.4 Viscosity measurements -- 3.5 Circular dichroism spectroscopy -- 3.6 Cyclic voltammetry.
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3.7 Melting temperature studies -- 3.8 NMR spectroscopy -- 3.9 X-ray crystallography -- 3.10 Molecular docking -- 4. Applications of manganese complexes -- 4.1 Manganese complexes as DNA-interacting agents -- 4.2 Manganese complexes as RNA-interacting agents -- 4.3 Manganese complexes as other biomolecule-interacting agents -- 4.3.1 DNA topoisomerases (Topo I/Topo II) -- 4.3.2 Serum proteins (HSA/BSA) -- 4.3.3 RNase -- 4.3.4 Lipids -- 4.3.5 Peptides -- 5. Limitations -- 6. Future prospects -- 7. Conclusion -- References -- Index -- Back Cover.
Weitere Ausg.:
Print version: Haq Bhat, Irshad Ul Nucleic Acids San Diego : Elsevier Science & Technology,c2023 ISBN 9780128205037
Sprache:
Englisch
