UID:
almahu_9949697344102882
Umfang:
1 online resource (792 pages)
Ausgabe:
2nd ed.
ISBN:
1-281-01225-4
,
9786611012250
,
0-08-049777-2
Inhalt:
Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity
Anmerkung:
Front Cover; The Practice of Medicinal Chemistry; Copyright Page; Contents; Biography; Contributors; Foreword; Preface to the First Edition; Preface to the Second Edition; Part I: General Aspects of Medicinal Chemistry; Chapter 1. A brief history of drugs: from plant extracts to DNA technology; Chapter 2. Medicinal chemistry: definition and objectives, the three main phases of drug activity, drug and disease classifications; Chapter 3. Measurement and expression of drug effects; Chapter 4. Drug targets: molecular mechanisms of drug action; Part II: Lead Compound Discovery Strategies
,
Chapter 5. Strategies in the search for new lead compounds or original working hypotheses; Chapter 6. Natural products as pharmaceuticals and sources for lead structures; Chapter 7. Basics of combinatorial chemistry; Chapter 8. The contribution of molecular biology to drug discovery; Chapter 9. Electronic screening: lead finding from database mining; Chapter 10. High-speed chemistry libraries: assessment of drug-likeness; Chapter 11. Web alert-using the internet for medicinal chemistry; Part III: Primary Exploration of Structure-Activity Relationships
,
Chapter 12. Molecular variations in homologous series: vinylogues and benzologues; Chapter 13. Molecular variations based on isosteric replacements; Chapter 14. Conformational restrictions and/or steric hindrance in medical chemistry; Chapter 15. Conformational restriction and/or steric hindrance in medicinal chemistry; Chapter 16. Identical and non-identical twin drugs; Chapter 17. Optical isomerism in drugs; Chapter 18. Application strategies for the primary structure-activity relationship exploration
,
Part IV: Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships; Chapter 19. Specific substituent groups; Chapter 20. The role of functional groups in drug-receptor interactions; Chapter 21. Compound properties and drug quality; Chapter 22. Quantitative approaches to structure-activity relationships; Part V: Spatial Organization, Receptor Mapping and Molecular Modeling; Chapter 23. Stereochemical aspects of drug action I: conformational restriction, steric hindrance and hydrophobic collapse
,
Chapter 24. Pharmacophore identification and receptor mappingChapter 25. Three-dimensional quantitative structure-property relationships; Chapter 26. Protein crystallography and drug discovery; Chapter 27. Protein homology modelling and drug discovery; Chapter 28. The transition from agonist to antagonist activity: symmetry and other considerations; Chapter 29. Design of peptidomimetics; Part VI: Chemical Modifications Influencing the Pharmacokinetic Properties; Chapter 30. The fate of xenobiotics in living organisms; Chapter 31. Biotransformat; Chapter 32. Chemical mechanisms of toxicity: basic knowledge for designing safer drugsion reactions
,
English
Weitere Ausg.:
ISBN 0-12-744481-5
Sprache:
Englisch
