UID:
almahu_9949697521502882
Umfang:
1 online resource (537 p.)
ISBN:
1-283-83567-3
,
0-12-391465-5
Inhalt:
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), g
Anmerkung:
Description based upon print version of record.
,
Front Cover; Immune Biology of Allogeneic HematopoieticStem Cell Transplantation: Models in Discovery and Translation; Copyright; Contents; Contributors; Foreword; Abbreviations; Chapter 1 - Overview of the immune biology of allogeneic hematopoietic stem cell transplantation; Introduction; Immune rejection; Immune deficiency; GVHD pathophysiology; The graft-versus-leukemia effect; References; Chapter 2 - The HLA system in hematopoietic stem cell transplantation; Introduction; Classical HLA; The role of classical HLA in unrelated donor hematopoietic cell transplantation
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The clinical significance of non-classical HLA genes: HLA-E, (HLA-F), HLA-G and MIC genesConclusions; Acknowledgments; References; Chapter 3 - The impact of minor histocompatibility antigens in allogeneic stem cell transplantation; From immunobiology to the impact of mHags in GVHD and GVT; Murine mHags, challenges for the human system; Immunobiology and biochemical identity of mHags; Mechanisms of generation of mHags; The impact of individual mHags on GVHD and GVT; To match or to mismatch: paradigm shifts in the mHag field; Hematopoietic mHags: ideal targets for separating GVT from GVHD
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Immunotherapeutic targeting of hematopoietic mHagsToward a broad and more effective application of mHag therapy; Controlling naturally existing and mHag-specific CD8+ regulatory T cells; Concluding remarks; References; Chapter 4 - In vivo imaging of graft-versus-host disease and graft-versus-leukemia; Introduction; Bioluminescence imaging; In vivo fluorescence imaging; Nuclear imaging (PET/SPECT); Magnetic resonance imaging; Multimodal imaging of GVHD and anti-tumor responses; Advances in imaging technology; Conclusion; References
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Chapter 5 - Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans)Introduction; Hematopoietic space and microenvironment; Effector mechanisms of graft rejection; Impact of pretransplant conditioning on effector mechanisms of rejection; Impact of MHC-matching on risk of rejection - from mice to humans; Impact of donor cells on risk of rejection - from mice to humans; Impact of post-transplant immunosuppression on risk of rejection; Future directions; References; Chapter 6 - Strategies to improve post-transplant immunity; Introduction
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Post-transplant immune deficiencyGVHD of the thymus; Interleukin-7; Keratinocyte growth factor; Sex steroid ablation; Growth hormone; T-cell precursors; Interleukin-22; Flt3L; Other cytokines and growth factors; Conclusions; References; Chapter 7 - Tumor-associated antigens; Introduction; Biology of tumor-associated antigens; Aberrantly expressed self-antigens; Tumor-specific antigens; Mutated self-antigens; Cellular approaches to targeting TAA; Unanswered questions; Conclusion; References; Chapter 8 - Impact of the conditioning regimen
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First evidence for a role of conditioning in pathophysiology of GVHD
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English
Weitere Ausg.:
ISBN 0-12-416004-2
Sprache:
Englisch
