UID:
edoccha_9959199704302883
Umfang:
1 online resource (various pagings) :
,
illustrations (some color).
ISBN:
1-64327-793-6
,
1-64327-792-8
Serie:
[IOP release 6]
Inhalt:
Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow.
Anmerkung:
"Version: 20191201"--Title page verso.
,
"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.
,
1. Background -- 1.1. Blood flow in human vasculature -- 1.2. Vascular targeting and margination of particles in blood flow -- 1.3. Adhesion of particles on endothelium wall
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part I. Numerical method -- 2. Numerical methods: fluid-structure interaction and adhesive dynamics -- 2.1. Fluid-structure interaction -- 2.2. Adhesive dynamics -- 2.3. Validation of numerical method
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part II. Applications -- 3. Anomalous vascular dynamics of nanoworms within blood flow -- 3.1. Motivation -- 3.2. Experimental and computational results
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4. Adhesion behavior of a single cell on the endothelial wall -- 4.1. Introduction -- 4.2. Computational model -- 4.3. Results and discussion
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5. Localization of soft particles: margination and adhesion -- 5.1. Introduction -- 5.2. Physical problem and computational method -- 5.3. Results and discussion
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6. Shape-dependent transport of micro-particles in blood flow: from margination to adhesion -- 6.1. Introduction -- 6.2. Computational model setup -- 6.3. Results and discussion
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7. Conclusion and perspective -- Appendix A. Coarse-grained potential for RBCs.
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Also available in print.
,
Mode of access: World Wide Web.
,
System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
Weitere Ausg.:
ISBN 0-7503-3019-8
Sprache:
Englisch
DOI:
10.1088/2053-2571/ab4124
