UID:
edoccha_9960073556102883
Umfang:
1 online resource (596 p.)
ISBN:
1-4832-1717-5
Serie:
Current topics in cellular regulation ; volume 18
Inhalt:
Current Topics in Cellular Regulation, Volume 18: Biological Cycles covers topics on the events of molecular biology, cellular communication, and the merging of cell structure to biochemical function. The book discusses the ornithin-urea cycle; the cycles of glutathione metabolism and transport; and the role of multienzymatic proteins in mammalian pyrimidine biosynthesis. The text also describes the significance of interconvertible enzyme cycles in cellular regulation; regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle; replenishment of citric
Anmerkung:
"Biological cycles, a symposium in honor of Sir Hans Krebs' 80th birthday, March 17, 18 - D1.600 and March 19 - D1.502, 9:00 a.m. to 4:00 p.m., the University of Texas Health Science Center at Dallas."
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Front Cover; Biological Cycles; Copyright Page; Table of Contents; List of Contributors and Discussants; Preface; Excerpts from an Interview with Sir Hans Krebs; Chapter 1. The Ornithine-Urea Cycle: Biosynthesis and Regulation of Carbamyl Phosphate Synthetase I and Ornithine Transcarbamylase; I. Historical Survey; II. Mitochondrial Enzymes Involved in Urea Biosynthesis; A. Carbamyl Phosphate Synthetase I; B. Ornithine Transcarbamylase; III. Effects of Mitochondrial Metabolites on Carbamyl Phosphate Synthetase I and Ornithine Transcarbamylase
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IV. Hormonal Effects on Citrulline and Urea BiosynthesisV. Effects of Dietary Protein on Citrulline and Urea Biosynthesis and the Enzymes Involved; VI. Synthesis and Degradation of Carbamyl Phosphate Synthetase I and Ornithine Transcarbamylase; VII. Discussion; Chapter 2. On the Cycles of Glutathione Metabolism and Transport; I. Introduction; II. The γ-Glutamyl Cycle; III. Function of the y-Glutamyl Cycle In Vivo; Effects of Amino Acid Administration and of Enzyme Deficiency and Inhibition; IV. Transport of Glutathione across Cell Membranes; V. Transport of γ-Glutamyl Amino Acids into Cells
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VI. Intraorgan and Interorgan Cycles of Glutathione MetabolismVII. Extracellular Oxidation of Glutathione to Glutathione Disulfide; VIII. On the Function of γ-Glutamyl Transpeptidase: Consequences of γ-Glutamyl Transpeptidase Inhibition; IX. Summary; Note Added in Proof; Chapter 3. Multienzymatic Proteins in Mammalian Pyrimidine Biosynthesis: Channeling of Intermediates to Avoid Futile Cycles; I. Introduction; II. Materials and Methods; III. Results; IV. The Metabolic Significance of Channeling of Pyrimidine Intermediates; Chapter 4. Interconvertible Enzyme Cycles in Cellular Regulation
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I. The Acyl-CoA Cycle in Clostridium kluyveriII. Interconvertible Enzyme Cycles in Metabolic Regulation; A. Monocyclic Cascade; B. Muticyclic Cascades; C. The Glutamine Synthetase Cascade; D. Cooperativity (Sensitivity) and Signal Amplification; III. Discussion; Chapter 5. Regulation of Mammalian Pyruvate Dehydrogenase Complex by a Phosphorylation-Dephosphorylation Cycle; I. Introduction; II. Subunit Composition and Structure; III. Regulation of Mammalian Pyruvate Dehydrogenase Complex; IV. Conclusions: The Domain Hypothesis
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Chapter 6. Replenishment of Citric Acid Cycle Intermediates by the Purine Nucleotide Cycle in Rat Skeletal MuscleI. Introduction; II. Demonstration of the Operation of the Purine Nucleotide Cycle in Extracts of Skeletal Muscle; III. Demonstration of the Operation of the Purine Nucleotide Cycle in Intact Skeletal Muscle; IV. Generation of Citric Acid Cycle Intermediates during Operation of the Purine Nucleotide Cycle; V. Discussion; Chapter 7. Control of a Secondary Pathway of Ethanol Metabolism by Differences in Redox State: A Story of the Failure to Arrest the Krebs Cycle for Drunkenness
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I. Introduction
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English
Weitere Ausg.:
ISBN 1-322-20426-8
Weitere Ausg.:
ISBN 0-12-152818-9
Sprache:
Englisch
