Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (272 pages)

Ausgabe: 1st ed.

ISBN: 9783031661525

Serie: Interdisciplinary Cancer Research Series ; v.8

Anmerkung: Intro -- Preface -- Contents -- About the Editor -- Interdisciplinary Approach in Lung Cancers -- 1 Introduction -- 2 Epidemiology -- 3 Screening -- 4 Clinical Manifestations and Diagnosis -- 5 Classification -- 6 Treatment -- 7 Conclusion -- References -- Fundamental Elements of a High-Functioning Lung Cancer Multidisciplinary Team (MDT) -- 1 Introduction -- 1.1 Multidisciplinary Team -- 1.2 Leadership -- 1.3 Team Collaboration -- 1.4 The MDT Venue -- 1.5 Data -- 1.6 MDT Billing -- 1.7 Biobank -- 1.8 Research -- 2 Conclusion -- References -- Epithelial to Mesenchymal Transition in Lung Cancer: When It Starts? -- 1 Introduction: EMT in Early-Stage Lung Cancer -- 2 EMT Phenotype in Early-Stage Lung Cancer -- 2.1 Regulatory Genes of EMT in Early-Stage Lung Cancer -- 2.2 Circulating Tumor Cells in Early-Stage EMT in Lung Cancer -- 2.3 Lymph Node Status and Phenotypic Transition in Early-Stage EMT -- 3 The Roles of ncRNA in EMT Regulation in Early-Stage Lung Cancer -- 3.1 miRNAs in EMT Regulation in Lung Cancer -- 3.2 lncRNAs in EMT in Early-Stage Lung Cancer -- 4 EMT as Mechanisms of Resistance to Conventional and Targeted Therapies in Lung Cancers: Correlations with Different Treatmen... -- 4.1 Adjuvant Treatment Setting as a Potential Early Time Point for EMT -- 4.2 First-Line Treatment of Advanced and Metastatic Lung Cancer Harboring Actionable Mutations as a Potential Early Time Point... -- 5 Conclusion -- References -- Roles of Tumor Immune Microenvironment in Non-small Cell Lung Cancer -- 1 Introduction -- 2 Interaction Between Tumor and TIME -- 2.1 Tumor Intrinsic Factors -- 2.1.1 Immunogenic Hot Tumors -- 2.1.2 Immunosuppressive Cold Tumors -- 2.1.3 Premalignant Lesions -- 2.2 Immune Contexture -- 2.2.1 T Lymphocytes -- 2.2.2 B Lymphocytes -- 2.2.3 Natural Killer Cells -- 2.2.4 Macrophages -- 2.2.5 Neutrophils -- 2.2.6 Dendritic Cells. , 2.2.7 Myeloid-Derived Suppressor Cells (MDSCs) -- 3 Tertiary Lymphoid Structures (TLSs) -- 4 TNM-I: TNM-Immunoscore in NSCLC -- 4.1 Location and Compartments of Immune Cells Within the Tumor -- 4.2 Scoring Method: Manual or Digital? -- 4.3 Whole Slides or Tissue Microarrays -- 5 Conclusion -- References -- Natural Killer Cells in Lung Cancer -- 1 Introduction -- 1.1 Non-small-cell Lung Cancer -- 1.2 Small-Cell Lung Cancer -- 2 Natural Killer Cells -- 2.1 Development and Maturation -- 2.2 NK Cell Cytotoxicity -- 3 Natural Killer Cells and Lung Cancer -- 3.1 NK Cell-Based Immunotherapies in Lung Cancer -- 4 Conclusion -- References -- RNA-binding Proteins as a New Link Between COPD and Lung Cancer -- 1 Introduction -- 2 RNA-binding Proteins (RBPs) as Mediator of Post-transcriptional Gene Regulation (PTGR) -- 3 RBPs in COPD Pathogenesis -- 4 RBPs in Modulating the Inflammation of Lower Airways -- 5 RBPs in Modulating IL-33 Signaling Pathway and COPD -- 6 RBPs in Modulating Drugs Response in COPD -- 7 RBPs in Lung Cancer Pathogenesis -- 8 Non-small Cell Lung Cancer (NSCLC) -- 9 Small Cell Lung Cancer (SCLC) -- 10 RBPs in Modulating IL-33 Signaling Pathway and Lung Cancer -- 11 The Role of RBPs in Mechanisms Linking COPD and Lung Cancer -- 12 Conclusion -- References -- The Implication of miRNA Signature in the Characteristic Features and Diagnosis of Lung Cancer -- 1 Introduction -- 1.1 Lung Cancer -- 1.2 MicroRNA -- 1.3 Biogenesis of miRNA -- 2 Impact of miRNA Signatures in Targeting the Various Characteristics of LC -- 2.1 Sustaining Proliferative Signaling in LC -- 2.2 Evading Growth Suppressors in LC -- 2.3 Resisting Cell Death in LC -- 2.4 Enabling Replicative Immortality in LC -- 2.5 Inducing Angiogenesis -- 2.6 Activating Invasion and Metastasis in LC -- 2.7 Deregulating Cellular Energetic in LC -- 2.8 Avoiding Immune Destruction in LC. , 2.9 Tumor-Promoting Inflammation -- 2.10 Genome Instability and Mutation -- 3 MicroRNA as Diagnostic Markers in LC -- 3.1 Biomarkers -- 3.2 miRNA as Noninvasive Diagnostic Markers -- 3.3 miRNA as Biomarker in Histological Subtype Identification -- 3.4 miRNA as a Biomarker in the Differentiation of Tumors -- 4 Conclusion and Perspectives -- References -- MicroRNAs in the Immunopathology and Treatment of Non-small Cell Lung Cancer -- 1 Introduction -- 1.1 Statistics of NSCLC -- 2 sncRNAs in Development of NSCLC -- 3 sncRNAs as Markers of Efficacy of Treatment -- 4 Surgery -- 5 Radiotherapy -- 6 Chemotherapy -- 6.1 Platinum Derivatives -- 6.2 Taxanes -- 7 Immune Therapy -- 7.1 Immunopathology of NSCLC -- 7.2 EGFR -- 7.3 PD/PD-L1 -- 7.4 CTLA-4 -- 8 MicroRNA-Based Therapy -- 8.1 Application Schemas -- 9 Side Effects and Complications -- 9.1 Conventional Therapy -- 9.2 MicroRNA-Based Therapy -- 10 Conclusion -- References -- Monitoring Exosomal Non-coding RNA in Lung Cancers -- 1 Introduction -- 2 Non-coding RNAs -- 2.1 MicroRNAs -- 2.2 Long Non-coding RNAs -- 3 Exosomes -- 3.1 Exosome Biogenesis -- 3.2 Exosomes Cargo -- 3.3 Exosomes in Cancer -- 4 Non-coding RNAs as Biomarkers in Lung Cancer -- 4.1 Exosome-Derived miRNAs and Lung Cancer Proliferation -- 4.2 Exosome-Derived miRNAs and Angiogenesis -- 4.3 Exosome-Derived ncRNAs and EMT/MET -- 4.4 Exosomal miRNAs Underlying Cisplatin Resistance -- 5 Exosome-Derived miRNAs and Their Diagnostic and Clinical Relevance -- 6 Conclusion -- References -- Mediastinal Staging of Lung Cancer -- 1 Introduction -- 2 Imaging Techniques -- 3 Non-surgical Techniques: Diagnostic Procedures in Interventional Pulmonology -- 3.1 Transbronchial Needle Aspiration -- 3.2 Endobronchial Ultrasound-TBNA -- 3.3 Esophageal Ultrasound-Guided Fine Needle Aspiration -- 3.4 EBUS-TBNA and EUS-FNA Technique -- 3.5 Samples. , 3.6 Safety and Contraindications -- 3.7 Use of Combination Techniques -- 3.8 Transthoracic Needle Aspiration -- 3.9 Lymph Node Cryobiopsy -- 3.10 Rapid On-Site Evaluation -- 3.11 Endobronchial Elastography -- 4 Surgical Techniques -- 4.1 Mediastinoscopy -- 4.2 Transcervical Extended Mediastinal Lymphadenectomy -- 4.3 Video-Assisted Mediastinoscopic Lymphadenectomy -- 4.4 Video-Assisted Thoracic Surgery -- 4.5 Robotic-Assisted Thoracic Surgery -- 5 Restaging After Oncologic Therapy -- 5.1 Imaging -- 5.2 EBUS-TBNA -- 5.3 Surgical Techniques -- 6 Restaging After Surgery -- 7 Conclusion and Future Perspectives -- References -- Pleural Mesothelioma: The Importance of Working Together -- 1 Introduction -- 2 Histopathological Classification -- 3 Genetic Mutations -- 4 Gene Expression Modulation -- 5 Diagnosis -- 6 Treatment -- 7 The Importance of Working Together -- References -- Comprehensive Genomic Profiling in Lung Cancer in the Era of Immunotherapy Approaches: The Role of Molecular Tumour Boards -- 1 Introduction -- 2 Efficacy of Immunotherapy in Advanced NSCLC Patients Harbouring EGFR Mutations or ALK Rearrangement -- 3 Efficacy of Immunotherapy in Advanced NSCLC Patients Harbouring Rare Oncogenic-Driven Alterations: The IMMUNOTARGET Registry -- 4 The Role of Molecular Tumour Boards: Experiences, Strengths and Limits -- 5 Conclusion -- References -- Index.

Weitere Ausg.: Print version: Rezaei, Nima Lung Cancer Pathophysiology: an Interdisciplinary Approach Cham : Springer International Publishing AG,c2024 ISBN 9783031661518

Sprache: Englisch