Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (514 pages) : , illustrations (some color), tables

Ausgabe: Second edition.

ISBN: 0-12-810420-1 , 0-12-810421-X

Anmerkung: Front Cover -- The Complement FactsBook -- The Complement FactsBook -- Copyright -- Contents -- List of Contributors -- Preface -- 1 - Introduction -- AIMS AND SCOPE OF THE BOOK -- ORGANISATION OF THE DATA -- Other Names -- Physicochemical Properties -- Structure -- Function -- Degradation Pathway -- Tissue Distribution -- Regulation of Expression -- Human Protein Sequence -- Protein Modules -- Chromosomal Location -- cDNA Sequence -- Genomic Structure -- Accession Numbers -- Deficiency -- Polymorphic Variants -- Mutant Animals -- REFERENCE -- 2 - The Complement System -- HISTORICAL PERSPECTIVE -- MODULAR STRUCTURE OF THE COMPONENTS -- The Collectins -- Serine Proteases -- C3 Family -- Terminal Pathway -- Regulatory Proteins -- The Leucocyte Receptors -- PATHWAYS -- Classical Pathway -- Lectin Pathway -- Alternative Pathway -- Terminal Pathway -- REFERENCES -- I - Collectins -- 3 - C1q -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- DEGRADATION PATHWAY -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- FURTHER READING -- 4 - Mannose-Binding Lectin -- OTHER NAMES OF MANNOSE-BINDING LECTIN -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 5 - Ficolins -- OTHER NAMES FOR FICOLINS -- PHYSICOCHEMICAL PROPERTIES -- FICOLIN-1 -- FICOLIN-2 -- FICOLIN-3 -- STRUCTURE -- FUNCTION -- Lectin and Binding Activities -- Binding of Ficolins to Microorganisms -- Lectin Pathway Activation. , Cross Talk and Collaboration of Ficolins With Noncomplement Proteins -- Roles in Homeostasis -- TISSUE DISTRIBUTION -- PROTEIN SEQUENCE -- PROTEIN MODULES -- Splicing Variants of Ficolins -- CHROMOSOMAL LOCATION -- CDNA SEQUENCE -- GENOMIC STRUCTURE -- Accession Numbers -- POLYMORPHIC VARIANTS -- FICOLIN-DEFICIENT MOUSE -- REFERENCES -- 6 - The Collectins -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- CRYSTAL STRUCTURE -- FUNCTION -- Sugar Specificity -- Ligand Specificity -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- II - Serine Proteases -- 7 - MASP-1 -- PHYSICOCHEMICAL PROPERTIES -- Immature Protein -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION16 -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 8 - MASP-2 -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION14 -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 9 - MASP-3 -- PHYSICOCHEMICAL PROPERTIES -- Immature Protein -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION18 -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 10 - C1r -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- 3D Structure -- FUNCTION. , TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE20-23 -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE22 -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 11 - C1s -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- 3D STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE26-28 -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE26 -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 12 - Factor D -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- DEGRADATION PATHWAY -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCES -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- FURTHER READING -- 13 - C2 -- PHYSIOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- EXPRESSION AND REGULATION -- PROTEIN SEQUENCE12,13 -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 14 - Factor B -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- PROTEIN SEQUENCES -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 15 - Factor I -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- PROTEIN SEQUENCES -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCES AND GENOMIC STRUCTURE. , POLYMORPHIC VARIANTS, DEFICIENCY AND DISEASE-RELATED SINGLE NUCLEOTIDE POLYMORPHISMS -- FI KNOCKOUT MICE -- REFERENCES -- III - C3 Family -- 16 - C3 -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- DEGRADATION PATHWAY -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 17 - C4 -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- PROTEIN SEQUENCE31 -- PROTEIN MODULES -- CHROMOSOMAL LOCATION33 -- CDNA SEQUENCE31,34 -- cDNA Sequence-Continued -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- Naturally Occurring C4 Deficiency -- C4 KNOCKOUT MOUSE PHENOTYPES -- REFERENCES -- 18 - C5 -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- DEGRADATION PATHWAY -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE3 -- HUMAN PROTEIN SEQUENCE-CONTINUED -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- HUMAN CDNA SEQUENCE-CONTINUED -- HUMAN CDNA SEQUENCE-CONTINUED -- Genomic Structure26,27 -- ACCESSION NUMBERS -- DEFICIENCY -- African-American Families28 -- Western Cape, South African Families29 -- Saudi Family30 -- Spanish Families31,32 -- Italian Family31 -- Brazilian Family33 -- Turkish Family34 -- Norwegian Family35 -- Danish Family35 -- Dutch Family36 -- Morocco Families37 -- POLYMORPHIC VARIANTS38 -- MUTANT ANIMALS -- REFERENCES -- IV - Terminal Pathway Components -- 19 - C6 -- PHYSIOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE1,2 -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE1,2. , GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 20 - C7 -- PHYSIOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE1 -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE1 -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 21 - C8 -- PHYSIOCHEMICAL PROPERTIES -- STRUCTURE -- CRYSTAL STRUCTURES -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- C8α19 -- C8β20, 21 -- C8γ22 -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- C8α19 -- C8β20, 21 -- C8γ22 -- GENOMIC STRUCTURE -- C8α24 -- C8β25 -- C8γ26 -- Polymorphic Variants -- MUTANT ANIMALS -- REFERENCES -- 22 - C9 -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- HUMAN CDNA SEQUENCE -- HUMAN CDNA SEQUENCE-CONTINUED -- GENOMIC STRUCTURE -- ACCESSION NUMBERS -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- V - Regulatory Proteins -- 23 - C1 Inhibitor -- PHYSICOCHEMICAL PROPERTIES -- Immature Protein -- Mature Protein -- STRUCTURE -- FUNCTIONS -- DEGRADATION PATHWAY -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- HUMAN PROTEIN SEQUENCE -- PROTEIN MODULES -- CHROMOSOMAL LOCATION -- CDNA SEQUENCE -- GENOMIC STRUCTURE -- DEFICIENCY -- POLYMORPHIC VARIANTS -- MUTANT ANIMALS -- REFERENCES -- 24 - C4b-Binding Protein -- OTHER NAMES -- PHYSICOCHEMICAL PROPERTIES -- STRUCTURE -- FUNCTION -- TISSUE DISTRIBUTION -- REGULATION OF EXPRESSION -- PROTEIN SEQUENCES -- PROTEIN MODULES -- CHROMOSOMAL LOCATION AND GENOMIC STRUCTURE -- CDNA SEQUENCES -- DEFICIENCY -- POLYMORPHIC VARIANTS AND DISEASE-RELATED SINGLE NUCLEOTIDE POLYMORPHISMS. , C4BP KNOCKOUT AND TRANSGENIC MICE.

Sprache: Englisch