Umfang:
Online-Ressource
Ausgabe:
Karger eBooks Collection 1997-2009
ISBN:
9783318002553
Serie:
Monographs in clinical neuroscience 16
Inhalt:
Stroke is the third leading cause of death in industrialized countries and the number one cause of disability in adults. Ischemic strokes constitute approximately 80% of all strokes, and until recently, no effective therapies had been available. The successful tissue plasminogen activator (tPA) trials open a new era of stroke management with a proven therapeutic now available to patients if they arrive at the hospital within hours of the onset of symptoms. Recent advances in our understanding of the molecular mechanisms of ischemic brain injury and vascular pathology have opened up new avenues for the development of novel therapeutic strategies. The premise that substantial reduction of brain damage after ischemic stroke by therapeutic intervention has now been confirmed in animal stroke models, sets a realistic goal for future treatment of stroke patients. This book covers topics ranging from fundamental molecular mechanisms of ischemic brain injury to the most current views on the clinical stroke trials and academic and industrial efforts to develop new drugs.The authors are leading authorities in their own fields in basic and clinical stroke research. As a timely and comprehensive volume, it will be of immense value to basic and clinical investigators, neurologists and neurosurgeons who manage stroke patients, neuroscientists interested in various aspects of brain injury, and researchers in the pharmaceutical industry who are engaged in new drug development
Anmerkung:
Includes bibliographical references and indexes
,
""Contents""; ""Preface""; ""Mechanisms of Ischemic Brain Injury Amenable to Therapeutic Interventions""; ""Glutamate Receptor-Mediated Neuronal Death in the Ischemic Brain1""; ""Oxygen Radical Mechanisms in Cerebral Ischemia and Reperfusion""; ""Nitric Oxide in Cerebrovascular Regulation and Ischemia""; ""Inflammatory Response and Adhesion Molecules in Focal Cerebral Ischemia""; ""Temperature Influences on Ischemic Brain Injury1""; ""Apoptosis""; ""Neurotrophic Factors""; ""New Drug Development""; ""Current Status of New Drug Development for Ischemic Stroke""
,
""New Magnetic Resonance Imaging Techniques for Stroke Diagnosis and Treatment""""Future Directions in Research and Development of New Treatments for Ischemic Stroke""; ""Author Index Subject Index""
Weitere Ausg.:
ISBN 9783805565608
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Hirnkrankheit
;
Ischämie
;
Schlaganfall
