UID:
almafu_9959326953602883
Format:
1 online resource (xii, 389 pages) :
,
illustrations
ISBN:
9780470409817
,
0470409819
,
9780470409800
,
0470409800
,
1282687549
,
9781282687547
,
9781118211571
,
111821157X
Content:
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scien.
Note:
Evolving role of mass spectrometry in drug discovery and development / Dil M. Ramanathan and Richard M. LeLacheur -- Quantitative bioanalysis in drug discovery and development : principles and applications / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen -- Quadrupole, triple-quadrupole, and hybrid linear ion trap mass spectrometers in metabolite analysis / Elliott B. Jones -- Applications of quadrupole time-of-flight mass spectrometry in reactive metabolite screening / Jose M. Castro-Perez -- Changing role of FTMS in drug metabolism / Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders -- High-resolution LC-MS based mass defect filter approach : basic concept and application in metabolite detection / Haiying Zhang [and others].
,
Applications of high-sensitivity mass spectrometry and radioactivity detection techniques in drug metabolism studies / Wing W. Lam [and others] -- Online electrochemical-LC-MS techniques for profiling and characterizing metabolites and degradants / Paul H. Gamache [and others] -- LC-MS methods with hydrogen/deuterium exchange for identification of hydroxylamine, n-oxide, and hydroxylated analogs of desloratadine / Natalia A. Penner [and others] -- Turbulent-flow LC-MS : applications for accelerating pharmacokinetic profiling and metabolite identification / Joseph L. Herman and Joseph M. Di Bussolo -- Desorption ionization techniques for quantitative analysis of drug molecules / Jason S. Gobey, John Janiszewski, and Mark J. Cole -- MALDI imaging mass spectrometry for direct tissue analysis of pharmaceuticals / Yunsheng Hsieh and Walter A. Korfmacher.
Additional Edition:
Print version: Mass spectrometry in drug metabolism and pharmacokinetics. Hoboken, N.J. : Wiley, ©2009 ISBN 9780471751588
Additional Edition:
ISBN 0471751588
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470409817
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409817
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409817
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409817
