UID:
edocfu_9960119818502883
Format:
1 online resource (xi, 246 pages) :
,
digital, PDF file(s).
Edition:
1st ed.
ISBN:
1-107-21533-1
,
0-511-85295-9
,
1-282-93173-3
,
9786612931734
,
0-511-93177-8
,
0-511-93043-7
,
0-511-93312-6
,
0-511-92792-4
,
0-511-93380-0
,
0-511-92538-7
Series Statement:
Cambridge medicine The placenta and human developmental programming
Content:
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Note:
Title from publisher's bibliographic system (viewed on 05 Oct 2015).
,
Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Chapter 1 Introduction; Chapter 2 The maternal and placental origins of chronic disease; Chapter 3 Pre-and periconceptual health and the HPA axis: Nutrition and stress; Chapter 4 Nutrition and preimplantation development; Chapter 5 Maternofetal transport pathways during embryogenesis and organogenesis; Chapter 6 Imprinted genes and placental growth: Implications for the developmental origins of health and disease
,
Chapter 7 Genomic imprinting: Epigenetic control and potential roles in the developmental origins of postnatal health and diseaseChapter 8 Trophoblast invasion and uterine artery remodelling in primates; Chapter 9 The role of the maternal immune response in fetal programming; Chapter 10 Clinical causes and aspects of placental insufficiency; Chapter 11 Uterine blood flow as a determinant of fetoplacental development; Chapter 12 Placental amino acid transporters: The critical link between maternal nutrition and fetal programming?
,
Chapter 13 Thematernal circulation and placental shape: Villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stressChapter 14 Glucocorticoids and placental programming; Chapter 15 Clinical biomarkers of placental development; Chapter 16 The placental roots of cardiovascular disease; Chapter 17 Placental function and later risk of osteoporosis; Chapter 18 Final general discussion; Chapter 19 The placenta and developmental programming: Some reflections; Index
,
English
Additional Edition:
ISBN 0-521-19945-X
Language:
English
