Format:
Online-Ressource (digital)
ISBN:
9783540737094
Series Statement:
SpringerLink
Content:
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
Content:
Summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. This book describes our knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction
Note:
Includes bibliographical references and index
,
Front Matter; Cellular versus Organismal Aging; Telomere-Induced Senescence of Primary Cells; Telomeres, Senescence, Oxidative Stress, and Heterogeneity; Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres; Telomerase Mutations and Premature Ageing in Humans; Mechanisms of Stem Cell Ageing; Senescence Signatures of Human Hematopoietic Stem Cells; Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function; p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
,
Telomerase as a Potential Regulator of Tissue Progenitor CellsTelomere Shortening and Telomerase Activation during Cancer Formation; Telomere Binding Proteins and Disease; Targeting Telomerase: Therapeutic Options for Cancer Treatment; Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?; Back Matter
Additional Edition:
ISBN 9783540737087
Additional Edition:
Buchausg. u.d.T. Telomeres and Telomerase in ageing, disease, and cancer Berlin : Springer, 2008 ISBN 9783540737087
Additional Edition:
ISBN 3540737081
Language:
English
Subjects:
Biology
Keywords:
Altern
;
Telomer
;
Krebs
;
Telomer
;
Adulte Stammzelle
;
Altern
;
Telomerase
;
Altern
;
Telomer
;
Krebs
;
Adulte Stammzelle
;
Telomerase
;
Aufsatzsammlung
DOI:
10.1007/978-3-540-73709-4
URL:
Volltext
(lizenzpflichtig)
Author information:
Rudolph, Karl Lenhard 1969-
