Format:
Online-Ressource (XVII, 519p. 78 illus., 21 illus. in color, digital)
ISBN:
9783642179693
Series Statement:
Handbook of Experimental Pharmacology 204
Content:
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Note:
Includes bibliographical references and index
,
Phosphodiesterases as Drug Targets; Index;
Additional Edition:
ISBN 9783642179686
Additional Edition:
Buchausg. u.d.T. Handbook of experimental pharmacology ; 204: Phosphodiesterases as drug targets Berlin : Springer, 2011 ISBN 9783642179686
Additional Edition:
ISBN 3642179681
Language:
English
Keywords:
Phosphodiesterasen
;
Enzyminhibitor
;
Arzneistoffträger
;
Aufsatzsammlung
