UID:
almafu_9959329135102883
Umfang:
1 online resource (4 volumes) :
,
illustrations
ISBN:
9783527619320
,
3527619321
,
3527308377
,
9783527308378
,
3527311300
,
9783527311309
,
3527314350
,
9783527314355
Serie:
Protein Degradation ; v. 9
Inhalt:
Annotation. This series of four topical volumes includes more than 50 contributions covering all aspects of the molecular biology and physiology of controlled protein breakdown in higher organisms via the ubiquitin-proteasome pathway. The editors and authors comprise virtually all the top scientists in the field, including the pioneers of protein degradation research and the 2004 Nobel laureate in chemistry. Each volume highlights a different aspect of the field, namely ubiquitin and the chemistry of life, as well as the cell biology and pathology of the ubiquitin-proteasome system, with the individual volumes featuring their own separate indices. Together, all four volumes provide the most comprehensive reference on protein degradation available.
Anmerkung:
v. 1, Ubiquitin and the chemistry of life -- v. 2, The ubiquitin-proteasome system -- v. 3, Cell biology of the ubiquitin-proteasome system -- v. 4, Ubiquitin-proteasome system and disease.
,
v. 1. Brief history of protein degradation and the ubiquitin system / Avram Hershko -- N-terminal ubiquitination: no longer such a rare modification / Aaron Ciechanover -- Evolutionary origin of the activation step during ubiquitin-dependent protein degradation / Hermann Schindelin -- RING fingers and relatives: determinators of protein fate / Kevin L. Lorick [and others] -- Ubiquitin-conjugating enzymes / Michael J. Eddins and Cecile M. Pickart -- The SCF ubiquitin E3 ligase / Leigh Ann Higa and Hui Zhang -- The structural biology of ubiquitin-protein ligases / Ning Zheng and Nikola P. Pavletich -- The deubiquitinating enzymes / Nathaniel S. Russell and Keith D. Wilkinson -- The 26S proteasome / Martin Rechsteiner -- Molecular machines for protein degradation / Matthias Bochtler [and others] -- Proteasome regulator, PA700 (19S regulatory particle) / George N. DeMartino and Cezary Wojcik -- Bioinformatics of ubiquitin domains and their binding partners / Kay Hofmann -- The COP9 signalosome: its possible role in the ubiquitin system.
,
v. 2. Molecular chaperones and the ubiquitin-proteasome system / Cam Patterson and Jörg Höhfeld -- Molecular dissection of autophagy in the yeast Saccharomyces cerevisiae / Yoshinori Ohsumi -- Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes / Huib Ovaa [and others] -- MEKK1: dual function as a protein kinase and a ubiquitin protein ligase / Zhimin Lu and Tony Hunter -- Proteasome activators / Andreas Förster and Christopher P. Hill -- The proteasome portal and regulation of proteolysis / Monika Bajorek and Michael H. Glickman -- Ubiquity and diversity of the proteosome system / Keiji Tanaka, Hideki Yashiroda, and Shigeo Murata -- Proteasome-interacting proteins / Jean E. O'Donoghue and Colin Gordon -- Structural studies of large, self-compartmentalizing proteases / Beate Rockel, Jürgen Bosch, and Wolfgang Baumeister -- What the archaeal PAN -- proteasome complex and bacterial ATP-dependent proteases can teach us about the 26S proteasome / Nadia Benaroudj, David Smith, and Alfred L. Goldberg -- Biochemical functions of ubiquitin and ubiquitin-like protein conjugation / Mark Hochstrasser.
,
v. 3. Ubiquitin: A New Player in the Peroxisome Field -- The Ubiquitin Proteasome System and Muscle Development -- The COP9 Signalosome: Structural and Biochemical Conservation and Its Roles in the Regulation of Plant Development -- Ubiquitin and Protein Sorting to the Lysosome -- ISG15-dependent Regulation -- The Role of the UbiquitinProteasome Pathway in the Regulation of the Cellular Hypoxia Response -- p97 and Ubiquitin: A Complex Story -- Cdc48 (p97) and Its Cofactors -- Deubiquitinating Enzymes, Cell Proliferation, and Cancer.
,
v. 4. Ubiquitin Signaling and Cancer Pathogenesis -- Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules -- The UbiquitinProteasome System in Epstein-Barr Virus Infection and Oncogenesis -- HECT Ubiquitin-protein Ligases in Human Disease -- Ubiquitin-independent Mechanisms of Substrate Recognition and Degradation by the Proteasome -- Endoplasmic Reticulum Protein Quality Control and Degradation -- Interactions between Viruses and the UbiquitinProteasome System.
Weitere Ausg.:
Print version: ISBN 9783527308378
Weitere Ausg.:
ISBN 3527308377
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9783527619320
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527619320
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527619320
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527619320
