Format:
1 Online-Ressource (XIV, 148 Seiten, 7800 KB)
,
Illustrationen, Diagramme
Content:
Deoxyribonucleic acid (DNA) nanostructures enable the attachment of functional molecules to nearly any unique location on their underlying structure. Due to their single-base-pair structural resolution, several ligands can be spatially arranged and closely controlled according to the geometry of their desired target, resulting in optimized binding and/or signaling interactions. This dissertation covers three main projects. All of them use variations of functionalized DNA nanostructures that act as platform for oligovalent presentation of ligands. The purpose of this work was to evaluate the ability of DNA nanostructures to precisely display different types of functional molecules and to consequently enhance their efficacy according to the concept of multivalency. Moreover, functionalized DNA structures were examined for their suitability in functional screening assays. The developed DNA-based compound ligands were used to target structures in different biological systems. One part of this dissertation attempted to bind pathogens ...
Note:
Dissertation Universität Potsdam 2021
Additional Edition:
Erscheint auch als Druck-Ausgabe Möser, Christin Modular DNA constructs for oligovalent bio-enhancement and functional screening Potsdam, 2021
Language:
English
Keywords:
DNS
;
Nanostruktur
;
Funktionelle Gruppe
;
DNS-Origami
;
Epitop
;
Antikörper
;
Chemische Bindung
;
Hochschulschrift
DOI:
10.25932/publishup-50728
URN:
urn:nbn:de:kobv:517-opus4-507289
URL:
https://d-nb.info/1265013470/34
Author information:
Fritzsche, Wolfgang 1965-
Author information:
Bald, Ilko 1980-
