Format:
Online-Ressource
ISSN:
1476-4598
Content:
Background: Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis. Animal model systems show that MLL gain of function mutations may contribute to leukemogenesis. Wild-type (wt) MLL possesses histone methyltransferase activity and functions at the level of chromatin organization by affecting the expression of specific target genes. While numerous MLL fusion proteins exert a diverse array of functions, they ultimately serve to induce transcription of specific genes. Hence, acute lymphoblastic leukemias (ALL) with MLL mutations (MLLmu) exhibit characteristic gene expression profiles including high-level expression of HOXA cluster genes. Here, we aimed to relate MLL mutational status and tumor suppressor gene (TSG) methylation/expression in acute leukemia cell lines. ...
In:
Molecular cancer, London : Biomed Central, 2002-, Band 8, Heft 86 (2009), 1476-4598
In:
volume:8
In:
year:2009
In:
number:86
In:
extent:11
Language:
English
DOI:
10.1186/1476-4598-8-86
URN:
urn:nbn:de:hebis:30-71038