UID:
almafu_9959326955502883
Format:
1 online resource (xxii, 330 pages, 8 unnumbered pages of plates) :
,
illustrations (some color)
ISBN:
9780470409107
,
047040910X
,
9780470409053
,
0470409053
,
1281938688
,
9781281938688
Content:
Providing an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development, this book equips drug development scientists with an interdisciplinary understanding of these receptors and how to regulate them. This aids in pharmaceutical research to target drugs and treat diseases like cancer, coronary heart disease, and diabetes. A single source for researchers, this book collects material otherwise scattered among journals, and adds background and applications data to make the chapters more comprehensive.
Note:
Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.
Additional Edition:
Print version: Nuclear receptors in drug metabolism. Hoboken, NJ : John Wiley & Sons, ©2009 ISBN 0470086793
Additional Edition:
ISBN 9780470086797
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470409107
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107
