UID:
almafu_9959327398402883
Umfang:
1 online resource (xi, 279 pages, 8 unnumbered pages of plates) :
,
illustrations (some color)
ISBN:
9780470377789
,
047037778X
,
9780470378076
,
0470378077
,
1281382116
,
9781281382115
Inhalt:
This is the first book specifically on galectins?a challenging and promising area in medical biochemistry and drug design. After an introduction to galectins, the book covers their structure and functions, ligand specificity, and molecular mechanisms of action, along with the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity. Then it covers the effect of galectins on cell migration, angiogenesis, and chemoresistance and describes new approaches to designing galectin inhibitors. This is a core reference for chemists, biochemists, pharmacologists, biologists.
Anmerkung:
GALECTINS; CONTENTS; Preface; Contributors; 1 Stumbling on Galectins; 2 Galectins and Their Functions in Plain Language; 3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists; 4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design; 5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing; 6 Galectins in Regulation of Inflammation and Immunity.
,
7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"?8 The Role of Galectins in Organ Fibrosis; 9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance; 10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia; 11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options; 12 Food-Related Carbohydrate Ligands for Galectins; Index.
Weitere Ausg.:
Print version: Galectins. Hoboken, N.J. : Wiley, ©2008 ISBN 9780470373187
Weitere Ausg.:
ISBN 0470373180
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470378076
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470378076
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470378076
